叶黄素的生物学作用及制剂研究进展

发布时间：2018-03-30 03:16

本文选题：叶黄素　切入点：理化性质　出处：《中国药房》2017年04期

【摘要】：目的:为叶黄素的制剂研究提供参考。方法:以"叶黄素""药理作用""剂型""应用""Lutein""Antioxidant"等为关键词,组合查询2006年1月-2016年7月在Pub Med、Elsevier、中国知网、万方、维普等数据库中的相关文献,对叶黄素的理化性质、体内过程、抗氧化活性、生物学作用、剂型研究及应用现状等方面进行综述。结果与结论:共检索到相关文献696篇,其中有效文献47篇。叶黄素含有独特的紫罗酮环二羟基结构,可作为强抗氧化剂淬灭单线态氧和蓝光过滤器,具有抗氧化、抗癌、保护视网膜、预防心血管疾病等生物学作用。但叶黄素的理化性质不稳定,在制剂过程中存在水溶性差、性质不稳定和生物利用度低等问题;叶黄素在体内只能与脂类结合吸收,这一特点大大制约了其药效的发挥。通过物理包埋和化学改性(如酯化反应)等方法改变剂型,并利用超微粉碎和微囊化等技术将叶黄素制备成油悬浮液、水分散性干粉、微胶囊和脂质体,能较好地解决这些问题。但如何进一步提高叶黄素的生物利用度、减小对胃肠道作用的影响、改善传统制剂粒径过大等问题还有待进一步研究。
[Abstract]:Objective: to provide reference for the study of lutein preparation.Methods: using "lutein" "pharmacological action" "dosage form" "Lutein" and "Antioxidant" as the key words, the authors combined and inquired about the physical and chemical properties and in vivo process of lutein in Pub Medsite Elsevier, China Zhiwang, Wanfang, Weip and other databases from January 2006 to July 2016.The antioxidant activity, biological action, dosage form research and application status are reviewed.Results & conclusion: a total of 696 related literatures were retrieved, of which 47 were valid.Lutein has a unique structure of azolone ring dihydroxyl group and can be used as a powerful antioxidant to quench singlet oxygen and blue light filters. Lutein has many biological functions such as antioxidation anticancer protection of retina and prevention of cardiovascular diseases.However, the physicochemical properties of lutein are unstable, the water solubility is poor, the property is unstable and the bioavailability is low. Lutein can only be absorbed by lipids in vivo, which greatly restricts its pharmacodynamics.The preparation of lutein into oil suspension, water dispersible dry powder, microcapsule and liposome was prepared by physical entrapment and chemical modification (such as esterification reaction), and the preparation of lutein into oil suspensions, water dispersible dry powders, microcapsules and liposomes by ultramicro pulverization and microencapsulation.Can solve these problems well.However, how to further improve the bioavailability of lutein, reduce the effect on gastrointestinal tract, and improve the particle size of traditional preparations need to be further studied.
【作者单位】：解放军第411医院药学科;江西中医药大学药学院;
【分类号】：R943

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