TPGS修饰多烯紫杉醇前体囊泡口服递药系统的构建及表征

发布时间：2018-04-14 15:02

本文选题：多烯紫杉醇 + 前体囊泡　；参考：《中国中药杂志》2015年19期

【摘要】：该研究旨在建立一种新型的载多烯紫杉醇的TPGS修饰前体囊泡口服递药系统(Doce-TPGS-PN),并对其水化后的物理化学特性和体外释放进行考察。首先,以制得前囊泡水化后的粒径、包封率和突释量为指标,考察脂质材料的种类、TPGS修饰方法、TPGS加入量及表面活性剂和胆固醇的比例对前囊泡水化后性质的影响,筛选最优处方和制备工艺。其次,对最优处方制得DTX-TPGS-PN的形态、粒径、表面电荷、包封率及体外释放行为进行考察。结果表明,Doce-TPGS-PN系统水化后,粒径为(93±6.5)nm,Zeta电位为(-83.95±3.69)m V,包封率(97.31±0.60)%,在PBS中的释放分为前0.5 h的速释相和之后的缓释相。实验证明,该研究成功构建了Doce-TPGS-PN这一新型口服给药系统,且其具有良好性质。
[Abstract]:The aim of this study was to establish a novel doce-TPGS-PNN system with paclitaxel loaded TPGS modified precursor vesicles, and to investigate its physicochemical properties and in vitro release after hydration.Firstly, the particle size, entrapment efficiency and sudden release of the prepared anterior vesicle after hydration were used as indexes to investigate the effects of the type of lipid materials modified by TPGS and the ratio of surfactant to cholesterol on the properties of the vesicle after hydration.To select the best prescription and preparation technology.Secondly, the morphology, particle size, surface charge, encapsulation efficiency and in vitro release behavior of DTX-TPGS-PN were investigated.The results showed that after hydration of Doce-TPGS-PN system, the particle size was 93 卤6.5nmGS-PN, the Zeta potential was -83.95 卤3.69mV, the entrapment efficiency was 97.31 卤0.60mV, and the release in PBS was divided into two phases: the first 0.5 h rapid release phase and the later slow release phase.The experimental results show that Doce-TPGS-PN, a new oral drug delivery system, is successfully constructed and has good properties.
【作者单位】：上海中医药大学穆拉德研究中心;
【基金】：上海市科委纳米专项(11nm0506700)
【分类号】：R943

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