紫杉醇致肌肉酸痛发生情况分析及治疗

发布时间：2018-04-26 05:34

本文选题：双氯芬酸钠 + 氨酚曲马多　；参考：《中国药房》2017年15期

【摘要】：目的:观察紫杉醇所致肌肉酸痛的发生情况,并观察双氯芬酸钠治疗的疗效和安全性。方法:84例接受紫杉醇化疗的恶性肿瘤患者中共有56例出现紫杉醇所致肌肉酸痛,其中22例女性患者发生中、重度肌肉酸痛,将其随机分为A组(11例)和B组(11例)。A组患者给予双氯芬酸钠缓释片75 mg,口服,每日1次;B组患者给予氨酚曲马多片1片,口服,每日1次,肌肉酸痛难以忍受时给予盐酸布桂嗪注射液100 mg,皮下注射,每日2~3次。两组疗程均为5 d。观察患者肌肉酸痛分布情况及疼痛出现时间和持续时间,A、B组患者疼痛缓解情况及不良反应发生情况。结果:84例患者中,肌肉酸痛发生率为66.67%,其中轻度疼痛占23.81%,中度疼痛占13.10%,重度疼痛占29.76%。56例肌肉酸痛患者中,疼痛最早出现在给药当天,大多数患者出现在用药1~3 d后,主要表现为酸痛,严重疼痛时活动受限,多数伴乏力。A、B组患者疼痛缓解率均为100%,但A组患者不良反应发生率显著低于B组,差异有统计学意义(P0.05)。结论:双氯芬酸钠治疗紫杉醇所致肌肉酸痛的疗效与氨酚曲马多相当,且安全性优于氨酚曲马多。
[Abstract]:Aim: to observe the occurrence of myalgia induced by paclitaxel and the efficacy and safety of diclofenac sodium. Methods among 84 patients with malignant tumor received taxol chemotherapy, 56 cases developed muscle soreness caused by paclitaxel, 22 of which suffered from moderate and severe muscle soreness. They were randomly divided into two groups: group A (n = 11) and group B (n = 11) were treated with diclofenac sodium sustained-release tablets (75 mg, orally), and group B (group B, once a day, with 1 tablet of paracetamol tramadol, once a day). When muscle soreness was unbearable, brunarizine hydrochloride was given 100 mg subcutaneously, 3 times a day. The course of treatment in both groups was 5 days. To observe the distribution of muscle soreness, the time of occurrence and duration of pain, the relief of pain and the occurrence of adverse reactions in group B. Results among 84 patients, the incidence of muscle soreness was 66.67. Mild pain accounted for 23.81%, moderate pain 13.10%, severe pain 29.766.56 cases. The pain first appeared on the day of administration, and most of the patients appeared after 1 day of treatment. The main symptoms were soreness and limited movement in severe pain. The relief rate of pain was 100 in most patients with fatigue. However, the incidence of adverse reactions in group A was significantly lower than that in group B (P 0.05). Conclusion: the efficacy of diclofenac sodium in the treatment of muscle soreness caused by paclitaxel is as good as that of aminophenol tramadol and its safety is superior to that of aminophenol tramadol.
【作者单位】：徐州医科大学附属医院药学部;徐州医科大学药学院;徐州医科大学附属医院肿瘤内科;
【分类号】：R979.1

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