胰岛素缓释载体材料应用研究与问题

发布时间：2018-05-09 09:32

本文选题：胰岛素 + 迟效制剂　；参考：《中国组织工程研究》2016年30期

【摘要】：背景:采用不同生物材料制备成微球形态作为胰岛素载体已成为研究热点。目的:总结胰岛素缓释微球的载体材料及制备方法。方法:应用计算机检索万方数据库和Pub Med数据库1997至2015年检索有关胰岛素缓释载体材料的文献,检索关键词为"胰岛素,缓释载体,生物材料,Insulin,Controlled-release Carrier,Biomaterials"。结果与结论:天然生物可降解高分子材料,包括明胶、海藻酸盐、壳聚糖及其衍生物等是胰岛素缓释微球载体的首选材料,具有良好的生物相容性、可降解性、成膜性或成球性好。人工合成生物可降解高分子作为载体材料,具有提高药物稳定性和有效利用率、实现药物靶向输送功能。根据不同材料的理化性质采用乳化-化学交联法、喷雾干燥法、溶剂挥发法等技术可制备符合不同要求的胰岛素缓释载体,为开发安全的药物载体提供了一条新途径。
[Abstract]:Background: the preparation of microspheres from different biomaterials as insulin carriers has become a hot topic. Objective: to summarize the carrier materials and preparation methods of insulin sustained release microspheres. Methods: the literature on insulin sustained-release carrier materials was searched by computer from 1997 to 2015 in Wanfang database and Pub Med database. The key words were "insulin, sustained-release carrier" and "insulin controlled-release Carriers-Biomaterials". Results & conclusion: natural biodegradable polymer materials, including gelatin, alginate, chitosan and their derivatives, are the first choice materials for insulin sustained release microspheres, and have good biocompatibility and degradability. Good film-forming or sphericity. Synthetic biodegradable polymers as carrier materials can improve the stability and effective utilization of drugs and realize the function of targeted delivery of drugs. According to the physical and chemical properties of different materials, the techniques of emulsification-chemical crosslinking, spray drying and solvent volatilization can be used to prepare insulin sustained-release carriers, which provide a new way for the development of safe drug carriers.
【作者单位】：首都医科大学附属北京妇产医院;
【分类号】：R943

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