五水头孢唑林钠对比头孢唑林钠治疗细菌感染的成本-效果分析

发布时间：2018-05-25 22:51

本文选题：五水头孢唑林钠 + 头孢唑林钠　；参考：《中国药房》2017年29期

【摘要】：目的:对比五水头孢唑林钠与头孢唑林钠治疗细菌感染的成本-效果,为临床合理用药提供参考。方法:采用回顾性研究方法,收集2014年11月-2015年12月我院使用五水头孢唑林钠或头孢唑林钠治疗细菌感染的患者207例,其中五水头孢唑林钠组109例、头孢唑林钠组98例。两组患者分别给予相应的药物2 g,bid,ivgtt,用药疗程不超过7 d。对比两组患者的临床疗效、细菌学疗效及安全性,并对两种治疗方案进行药物经济学评价。结果:五水头孢唑林钠组和头孢唑林钠组患者的临床有效率分别为89.91%和74.49%,差异有统计学意义(P0.05);细菌清除率分别为76.32%和72.13%,差异无统计学意义(P0.05)。两组患者用药期间均未见药物相关的不良反应发生。五水头孢唑林钠组和头孢唑林钠组方案的短期(7 d)治疗成本分别为4 391.43和3 396.19元,以临床有效率作为效果指标的成本-效果比分别为48.84、45.59,增量成本-效果比为64.55,小于我市人均国内生产总值。敏感度分析结果支持成本-效果分析结果。结论:在我市现有经济条件下,使用五水头孢唑林钠治疗细菌感染较头孢唑林钠更具有成本效果优势。
[Abstract]:Objective: to compare the cost-effect of cefazolin sodium pentahydrate and cefazolin sodium in the treatment of bacterial infection. Methods: a retrospective study was conducted in 207 patients with bacterial infection treated with cefazolin pentahydrate or cefazolin sodium in our hospital from November 2014 to December 2015, including 109 cases in cefazolin pentahydrate group and 98 cases in cefazolin sodium group. Patients in the two groups were given 2 g bidobium iv gtt for no more than 7 days. The clinical efficacy, bacteriological efficacy and safety of the two groups were compared. Results: the clinical effective rates of cefazolin sodium pentahydrate group and cefazolin sodium group were 89.91% and 74.49 respectively, the difference was statistically significant (P 0.05), and the bacterial clearance rates were 76.32% and 72.13%, respectively. There were no adverse drug-related reactions in both groups. The treatment cost of cefazolin pentahydrate sodium group and cefazolin sodium group was 4 391.43 yuan and 3 396.19 yuan respectively. The cost to effect ratio of clinical effective rate was 48.84% 45.59, and the incremental cost-effect ratio was 64.55, which was smaller than the per capita gross domestic product (GDP) of our city. Sensitivity analysis results support cost-effect analysis results. Conclusion: cefazolin sodium pentahydrate is more effective than cefazolin sodium in the treatment of bacterial infection.
【作者单位】：哈励逊国际和平医院药学部;
【分类号】：R956

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