二甲双胍对快速老化模型SAMP8小鼠行为学及生存率的影响

发布时间：2018-06-19 14:29

本文选题：二甲双胍 + SAMP小鼠　；参考：《中国老年学杂志》2017年19期

【摘要】：目的探讨二甲双胍对SAMP8小鼠行为学及生存率的影响。方法 40只雄性SAMP8小鼠分为二甲双胍低、中、高剂量实验组及空白对照组,实验组每日按小鼠体重灌胃不同浓度的二甲双胍,空白对照组每日灌胃生理盐水,观察小鼠的行为学指标及12月龄生存率。结果二甲双胍低、中、高剂量实验组小鼠行为学指标无明显变化;低、中、高剂量实验组12月龄小鼠生存率均高于空白对照组(P0.05)。结论二甲双胍对改善SAMP8小鼠学习记忆能力无显著影响,但可延长SAMP8雄性小鼠的12月龄生存率。
[Abstract]:Objective to investigate the effect of metformin on behavior and survival rate of SAMP8 mice. Methods 40 male SAMP8 mice were divided into low, medium and high dose metformin group and blank control group. The experimental group was given different concentrations of metformin daily according to the body weight of mice, and the blank control group was given normal saline daily. The behavioral indexes and 12-month survival rate of mice were observed. Results there was no significant change in behavioral indexes of mice in the low, middle and high dose metformin groups, and the survival rate in the low, medium and high dose groups was higher than that in the control group (P 0.05). Conclusion Metformin has no significant effect on improving the learning and memory ability of SAMP8 mice, but it can prolong the 12 month survival rate of SAMP8 male mice.
【作者单位】：北京大学医学部实验动物科学部;
【基金】：北京高等学校青年英才计划项目(No.YETP0057)
【分类号】：R-332;R965

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