氯吡格雷对家兔血小板聚集率与创伤性出血的影响

发布时间：2018-06-28 13:54

本文选题：氯吡格雷 + 血小板聚集率　；参考：《中国老年学杂志》2017年15期

【摘要】：目的观察氯吡格雷家兔血小板聚集率与创伤性出血的影响。方法选取21只健康家兔,随机分为3组,A组为对照组,给予生理盐水5 ml·kg-1·d-1灌胃,B、C组给予浓度为0.575 mg/ml的氯吡格雷药液5 ml·kg-1·d-1灌胃,B组连续灌胃7 d,C组连续灌胃14 d。检测3组家兔服药前、服药7、14 d的血小板聚集率、血小板计数,并检测各组家兔服药14 d的出血时间、凝血时间,记录创伤的出血量。结果 3组家兔服药前血小板聚集率及血小板计数无明显差异(P0.05)。服药后第7天,B、C组家兔血小板聚集率较A组明显降低(P0.001);第14天,B组家兔血小板聚集率与A组比较无显著差异(P0.05),出血时间无明显延长,创伤性出血量无明显增加(P0.05)。第14天C组血小板聚集率与A、B组相比显著降低(P0.001),C组的出血时间较A、B组显著延长(P0.01),创伤性出血量较A、B组有所增加,但无统计学差异(P0.05)。B、C组家兔凝血时间及血小板计数与A组比较无显著差异(P0.05)。创伤性出血量与血小板聚集率无显著相关性。结论不停用常规剂量的氯吡格雷未明显增加创伤性出血量;血小板聚集率暂不能作为术前停药的参考指标。
[Abstract]:Objective to observe the effect of clopidogrel on platelet aggregation and traumatic hemorrhage in rabbits. Methods Twenty-one healthy rabbits were randomly divided into three groups as control group. The control group was given normal saline 5 ml kg-1 d-1 intragastric infusion of clopidogrel solution 5 ml kg-1 d -1 for 14 days. The platelet aggregation rate, platelet count, bleeding time, coagulation time and wound bleeding volume were measured in 3 groups of rabbits before taking medicine for 7 days and 14 days after taking medicine. Results there was no significant difference in platelet aggregation rate and platelet count between the three groups (P 0.05). The platelet aggregation rate in group B was significantly lower than that in group A on day 7 (P0.001), but there was no significant difference between group B and group A on the 14th day (P0.05), the bleeding time was not significantly prolonged, and the amount of traumatic hemorrhage was not significantly increased (P0.05). On the 14th day, the platelet aggregation rate in group C was significantly lower than that in group A (P 0.001). The bleeding time in group C was significantly longer than that in group A (P 0.01), and the amount of traumatic bleeding was higher than that in group A (P 0.01). But there was no statistical difference (P0.05). There was no significant difference in coagulation time and platelet count between group A and group B (P0.05). There was no significant correlation between traumatic blood loss and platelet aggregation. Conclusion Clopidogrel does not increase the amount of traumatic blood loss and platelet aggregation rate can not be used as a reference index for withdrawal of drugs before operation.
【作者单位】：贵州医科大学附属医院;
【分类号】：R965

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