治疗短肠综合征新药:替度鲁肽
发布时间：2018-07-15 09:48
【摘要】：替度鲁肽为一重组胰高血糖素样肽-2类似物,具有增强肠吸收的作用,已经被几个国家批准用于需要肠外营养支持的短肠综合征(SBS)患者的治疗。试验表明替度鲁肽可增强SBS患者肠的吸收功能,促进肠黏膜生长。替度鲁肽最常见的不良反应表现为腹胀、鼻咽炎、外周水肿及食欲下降等。本文从药效学、药动学、临床疗效及安全性等方面对替度鲁肽作一综述。
[Abstract]:Tedolu peptide, a recombinant glucagon-like peptide-2 analogue, has been approved by several countries for treatment of short bowel syndrome (SBS) patients requiring parenteral nutrition support. The results showed that tidurosine could enhance intestinal absorption function and promote intestinal mucosal growth in SBS patients. The most common adverse effects of tidalutin are abdominal distension, nasopharyngeal inflammation, peripheral edema and loss of appetite. This article reviews the pharmacodynamics, pharmacokinetics, clinical efficacy and safety of tidolu peptide.
【作者单位】： 临沂市中心医院药学部;
【分类号】：R977
本文编号：2123671
[Abstract]:Tedolu peptide, a recombinant glucagon-like peptide-2 analogue, has been approved by several countries for treatment of short bowel syndrome (SBS) patients requiring parenteral nutrition support. The results showed that tidurosine could enhance intestinal absorption function and promote intestinal mucosal growth in SBS patients. The most common adverse effects of tidalutin are abdominal distension, nasopharyngeal inflammation, peripheral edema and loss of appetite. This article reviews the pharmacodynamics, pharmacokinetics, clinical efficacy and safety of tidolu peptide.
【作者单位】： 临沂市中心医院药学部;
【分类号】：R977
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