抗癌新药帕泊昔布胶囊含量测定方法的研究
发布时间:2018-07-20 15:28
【摘要】:目的:对帕泊昔布胶囊含量测定进行研究。方法:用高效液相色谱法(HPLC)测定,选用Kromasil C18色谱柱(250 mm×4.6 mm,5μm),流动相为乙腈:0.01 mol·L~(-1)醋酸钠缓冲液=30∶70;流速为1.0 m L·min~(-1);检测波长为260 nm;柱温30℃。峰面积按照外标法进行计算。结果:帕泊昔布在0.004 04~0.020 19 mg·mL~(-1)范围内线性良好,高、中、低3个浓度加样平均回收率分别为98.5%,99.1%和98.5%。测定3个不同批号样品的含量分别是99.3%,99.3%和98.9%。结论:该法操作快速简便、灵敏度高、专属性强,能够克服制剂中辅料对测定结果的干扰,也可用于该胶囊制剂的质量控制。
[Abstract]:Objective: to determine the content of Papoxib capsules. Methods: Kromasil C18 column (250mm 脳 4.6mm ~ 5 渭 m),) was used as mobile phase, acetonitrile: 0.01 mol L ~ (-1) sodium acetate buffer solution 30: 70, flow rate 1.0 mL 路min ~ (-1), detection wavelength 260 nm, column temperature 30 鈩,
本文编号:2133970
[Abstract]:Objective: to determine the content of Papoxib capsules. Methods: Kromasil C18 column (250mm 脳 4.6mm ~ 5 渭 m),) was used as mobile phase, acetonitrile: 0.01 mol L ~ (-1) sodium acetate buffer solution 30: 70, flow rate 1.0 mL 路min ~ (-1), detection wavelength 260 nm, column temperature 30 鈩,
本文编号:2133970
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