2005-2014年我国基本药物不良反应文献计量学分析

发布时间：2018-07-20 16:18

【摘要】：目的:了解我国基本药物不良反应文献的研究趋势及热点,为促进基本药物合理使用提供参考。方法:计算机检索2005-2014年中国知网数据库、万方数据库、维普数据库收录的基本药物不良反应相关文献,先运用书目信息共现分析系统(BICOMB)2.0版提取关键词、年份及相应文献量、期刊、作者及机构等参量进行文献计量学分析,并构建高频关键词词篇矩阵;然后将该词篇矩阵导入SPSS 21.0进行系统聚类分析;最后使用图形聚类工具包(gCLUTO)1.0版进行关键词词篇共现分析和聚类可视化分析。结果:共检索到文献232篇,刊登在100种期刊上,文献量呈逐年上升转稳态发展趋势;发文量最高的前4位作者分别为李幼平(13篇)和李鸿浩、王莉、杨晓妍(各10篇),发文量最多的前3个机构分别为广州中医药大学第二附属医院/广东省中医院(18篇)、国家食品药品监督管理总局药品评价中心(16篇)、四川大学华西医院中国循证医学中心(13篇)。高频关键词除了"药品不良反应""基本药物""基本药物目录""基本药物制度""分析"外,还有"合理用药""中药注射剂""药品说明书""抗菌药物""循证评价与遴选""乡镇卫生院";经关键词聚类分析可分为5类。结论:我国基本药物不良反应文献量趋于稳定,内容逐步深入,相关研究结论对促进基本药物合理、安全、有效的使用产生了积极影响,但文献多是从理论和宏观政策上进行论述,且来自药品生产企业的文献较少,儿童基本药物不良反应研究也较少。因此,该领域的研究仍需从定性转向定量,从简单的数据分析转向深入的机制研究,从宏观的政策建议转向微观的具体药物,以更好地促进基本药物合理使用,保障人民群众用药安全。
[Abstract]:Objective: to understand the research trend and hotspot of the literature on essential drug adverse reactions in China, and to provide a reference for the rational use of essential drugs. Methods: the essential adverse drug reactions (ADRs) were retrieved from 2005 to 2014 in the database of Chinese knowledge Network, Wanfang database and Weip database. The key words, year and corresponding literature quantity were extracted by Bibliographic Information Co-occurrence Analysis system (BICOMB) version 2.0. The journal, author and organization are analyzed by bibliometrics, and the high frequency keyword text matrix is constructed, and then the word text matrix is introduced into SPSS21.0 for systematic cluster analysis. Finally, the graphical clustering Toolkit (gCLUTO) 1.0 is used to analyze the cooccurrence of keywords and cluster visualization. Results: a total of 232 articles were retrieved and published in 100 journals. The number of papers was increasing year by year, and the top 4 authors were Li Youping (13 articles) and Li Honghao, Wang Li, respectively. Yang Xiaoyan (10 articles each), the top three organizations with the largest number of papers were the second affiliated Hospital of Guangzhou University of traditional Chinese Medicine / Guangdong Provincial Hospital of Chinese Medicine (18 articles), the Drug Evaluation Center of the State Administration of Food and Drug Administration (16 articles), Sichuan University China Evidence-based Medicine Center, West China Hospital (13). In addition to "adverse drug reactions", "essential drug catalogue", "essential drug system", "analysis", There are also "rational drug use", "traditional Chinese medicine injection", "drug instruction", "antimicrobial drug", "evidence-based evaluation and selection" and "township health center", which can be classified into 5 categories by keyword cluster analysis. Conclusion: the amount of literature on ADRs of essential drugs in our country tends to be stable and the contents are gradually deepening. The relevant research conclusions have a positive effect on promoting the rational, safe and effective use of essential drugs. But the literature is mostly discussed from the theory and the macroscopic policy, and the literature from the drug production enterprise is less, and the research of the children's essential drug adverse reaction is also less. Therefore, research in this area still needs to move from qualitative to quantitative, from simple data analysis to in-depth research on mechanisms, from macro-policy recommendations to micro-specific drugs, in order to better promote the rational use of essential drugs. To ensure the safety of drug use by the people.
【作者单位】：郑州大学药学院;郑州铁路职业技术学院药学系;河南省食品药品监督管理局;
【基金】：河南省科技攻关计划项目(No.142102310075)
【分类号】：R95;G353.1

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