紫杉醇药物荧光标记脂质体的制备及评价

发布时间：2018-07-28 10:05

【摘要】：目的:制备一种荧光量子点标记的紫杉醇药物脂质体。方法:以生物相容性良好的低分子聚合物、量子点制备紫杉醇荧光脂质体,采用均匀设计优化处方工艺,并用透射电镜、扫描电镜、荧光光谱和荧光倒置显微镜等对脂质体的外观形态、荧光性质、脂质体的包封率等进行分析研究。结果:制得紫杉醇药物荧光标记脂质体外观形态、粒度分布良好,包封率高,平均粒径(253±70.32)nm,具有良好的荧光标记性和稳定性。结论:得到的脂质体的分散性良好,包封率高,并具有显著的荧光特性。
[Abstract]:Objective: to prepare a fluorescent quantum dot labeled paclitaxel drug liposome. Methods: paclitaxel fluorescent liposomes were prepared from low molecular polymers with good biocompatibility. The formulation was optimized by uniform design. Transmission electron microscopy (TEM) and scanning electron microscopy (SEM) were used to prepare paclitaxel fluorescent liposomes. The appearance, fluorescence properties and encapsulation efficiency of liposomes were studied by fluorescence spectrum and fluorescence inverted microscope. Results: paclitaxel fluorescent labeled liposomes were prepared with good particle size distribution, high encapsulation efficiency and average particle size (253 卤70.32) nm, which showed good fluorescence labeling and stability. Conclusion: the obtained liposomes have good dispersibility, high entrapment efficiency and remarkable fluorescence properties.
【作者单位】： 浙江省宁海县第一医院药剂科;浙江省肿瘤医院;
【分类号】：R943

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