环境响应性纳米给药系统的研究进展

发布时间：2018-08-15 15:21

【摘要】：目的:为环境响应性纳米给药系统的设计提供新思路。方法:以"纳米给药系统""环境敏感制剂""药物释放""Nanometer drug delivery system""Drug release""pH-responsive""Redox-responsive"等为关键词,组合检索2000年1月-2016年2月在Web of Science、PubMed、ScienceDirect、中国知网、万方、维普等数据库中的相关文献,对纳米给药系统环境的敏感条件及其释药机制方面作简要综述。结果:共检索到相关文献237篇,其中有效文献26篇。常见的敏感条件有pH敏感、氧化还原敏感、热敏感、超声波敏感、光敏感等;此类给药系统在稳态中可保持稳定,但经环境刺激后可响应性改善纳米制剂的释药性能与结构、改变药物的释放位点、调控胞内药物代谢途径,发挥靶向治疗、快速释药的效果,提高肿瘤治疗的疗效。结论:本研究为设计性能更佳的纳米给药系统提供了一定的参考。后续研究需深入探索肿瘤微环境,充分了解外加刺激的性质以及环境响应性纳米聚合物的相关特性,以提高给药系统药物释放速率,增强疗效。
[Abstract]:Objective: to provide a new idea for the design of environmental responsive drug delivery system. Methods: using "nanometer drug delivery system", "environmental sensitive preparation", "drug release", "Nanometer drug delivery system", "Drug release", "pH-responsive" Redox-responsive "as the keywords, a combined search was conducted in the Web of ScienceSense PubMedence DirectNet, Wannfang, Weip and other databases from January 2000 to February 2016. The sensitive conditions and drug release mechanism of nano-drug delivery system are reviewed briefly. Results: a total of 237 related literatures were retrieved, of which 26 were valid. The common sensitive conditions are pH sensitivity, redox sensitivity, heat sensitivity, ultrasonic sensitivity, light sensitivity, etc. To change the release site of drugs, regulate the pathway of intracellular drug metabolism, give play to the effect of targeted therapy and rapid release of drugs, and improve the curative effect of tumor therapy. Conclusion: this study provides some reference for designing nanometer drug delivery system with better performance. In order to improve the drug release rate and enhance the efficacy of drug delivery system, further research is needed to explore the tumor microenvironment and fully understand the properties of external stimuli and the related properties of environmental responsive nano-polymers.
【作者单位】：泉州市第一医院药剂科;
【分类号】：R943

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