不同输注方式对帕拉西林-他唑巴坦钠临床疗效影响的Meta分析
发布时间：2018-12-16 16:17
【摘要】：目的:系统评价不同输注方式对帕拉西林-他唑巴坦钠临床疗效的影响。方法:在Pub Med,Web of Science,Pro Quest,Embase,Science Direct,Cochrane上检索所有2015年1月1日前所有相关文献,采用Revman 5.3软件进行分析。结果:共纳入2篇RCT和10篇观察性研究文献,结果显示延长给药组或连续给药组相对于传统给药方法,能降低临床死亡率[OR 0.68,CI(0.53,0.88),P=0.003],但临床有效率差异无统计学意义[OR 0.84,CI(0.83,2.50),P=0.20]。结论:帕拉西林-他唑巴坦钠采用延长或连续输注的方式可以降低死亡率,临床值得推荐。
[Abstract]:Objective: to evaluate the effect of different infusion modes on the clinical efficacy of paracillin-tazobactam sodium. Methods: all relevant literatures were searched on Pub Med,Web of Science,Pro Quest,Embase,Science Direct,Cochrane before January 1, 2015 and analyzed by Revman 5.3 software. Results: two articles of RCT and 10 articles of observational literature were included. The results showed that the prolonged or continuous administration group could reduce the clinical mortality rate compared with the traditional administration method [OR 0.68 CI (0.53 卤0.88), P0. 003]. But there was no significant difference in the clinical effective rate [OR 0.84 CI (0.83P 2.50), P < 0.20]. Conclusion: prolonged or continuous infusion of paracillin-tazobactam sodium can reduce mortality.
【作者单位】： 北京大学药学院;中国人民解放军军事科学院门诊部;北京大学附属第一医院药剂科;
【分类号】：R969.4
[Abstract]:Objective: to evaluate the effect of different infusion modes on the clinical efficacy of paracillin-tazobactam sodium. Methods: all relevant literatures were searched on Pub Med,Web of Science,Pro Quest,Embase,Science Direct,Cochrane before January 1, 2015 and analyzed by Revman 5.3 software. Results: two articles of RCT and 10 articles of observational literature were included. The results showed that the prolonged or continuous administration group could reduce the clinical mortality rate compared with the traditional administration method [OR 0.68 CI (0.53 卤0.88), P0. 003]. But there was no significant difference in the clinical effective rate [OR 0.84 CI (0.83P 2.50), P < 0.20]. Conclusion: prolonged or continuous infusion of paracillin-tazobactam sodium can reduce mortality.
【作者单位】： 北京大学药学院;中国人民解放军军事科学院门诊部;北京大学附属第一医院药剂科;
【分类号】：R969.4
【参考文献】
相关期刊论文 前1条
1 李园园;于锋;;哌拉西林钠-他唑巴坦钠优选给药方案的评估及应用的研究现状[J];药学实践杂志;2014年06期
【共引文献】
相关期刊论文 前8条
1 肖宇博;葛卫红;;β-内酰胺类抗菌药物的替代给药方案[J];实用药物与临床;2013年09期
2 黄云峰;向鹏;梅敏;;哌拉西林他唑巴坦联合阿米卡星治疗泛耐药铜绿假单胞菌性肺炎的效果[J];中国民族民间医药;2014年01期
3 何聪;申丽e，
本文编号：2382681
本文链接：https://www.wllwen.com/yixuelunwen/yiyaoxuelunwen/2382681.html
最近更新
教材专著
