棘白菌素对真菌生物被膜作用的文献计量分析

发布时间：2018-12-16 16:53

【摘要】：目的分析棘白菌素类药物对真菌生物被膜作用的相关文献,了解其研究现状。方法在中外文献数据库(Em Base,Pub Med,SCI,CNKI及Sino Med)检索2001年至2013年相关文献,用End Note X7软件进行分类整理,对纳入文献的发表年份、文献类型、国家、第一作者、期刊、被引频次及研究内容等进行计量分析。结果共纳入外文148篇,中文5篇,以论著为主。文献最高被引157次,研究最多的菌株是白色念珠菌,共62篇;棘白菌素类单用对念珠菌生物被膜研究最多,且以卡泊芬净对白色念珠菌研究最为深入,共24篇;棘白菌素联合用药研究共14篇,临床研究相对较少(3篇)。结论棘白菌素单用对真菌生物被膜有很好的抑制作用,尚未发现理想的联合治疗方案,未来研究重点是生物被膜相关体内感染模型和研究从基础向临床转化。
[Abstract]:Objective to analyze the effects of Echinoctonins on fungal biofilm and to find out the current research status. Methods Chinese and foreign literature databases (Em Base,Pub Med,SCI,CNKI and Sino Med) were used to retrieve relevant literature from 2001 to 2013. The published year, type, country, first author and periodical were classified and sorted by End Note X7 software. The frequency of citation and the contents of the research were analyzed. Results 148 articles in foreign language and 5 articles in Chinese were included. The most frequently cited strains were Candida albicans (62 papers), the biofilm of Candida albicans with acanthoctonin alone was the most studied, and the study of Candida albicans by Carbofen was the most thorough (24 papers). There were 14 studies on combined use of Echinocephalin, and there were relatively few clinical studies (3). Conclusion Echinocephalin alone has a good inhibitory effect on fungal biofilm, but no ideal combination therapy has been found. In the future, the focus of research is on the model of biofilm-associated infection in vivo and the transformation from basic to clinical.
【作者单位】：解放军总医院转化医学中心药物/器械临床试验中心;
【基金】：国家科技部十二五重大专项滚动课题基金资助项目(2012ZX09303004-002)
【分类号】：R96

【共引文献】