新型抗血小板药物替格瑞洛临床应用分析

发布时间：2019-07-22 17:50

【摘要】：目的:分析住院患者替格瑞洛使用情况,了解该药物的临床应用现状,为提高替格瑞洛的临床合理用药水平提供参考。方法:收集北京大学第一医院2014年1~6月住院期间使用替格瑞洛病历资料,回顾性分析使用替格瑞洛患者的适应症、用法用量、相互作用及不良反应等。结果:纳入分析的患者共36例,男性24例,女性12例;平均年龄(63.77±14.69)岁;体重(70.76±11.17)kg。原发病均为急性冠脉综合征、PCI手术。36例患者中,4例为阿司匹林联用替格瑞洛,30例为阿司匹林联用氯吡格雷后将氯吡格雷更换为替格瑞洛,1例为阿司匹林联用西洛他唑后将西洛他唑更换为替格瑞洛,1例为阿司匹林加用替格瑞洛。31例患者按说明书中所示的用法用量使用,5种患者使用其他不同的用法用量。涉及的可能与替格瑞洛存在相互作用的合并用药共8种。共6例次出现相关不良反应,其中2例(5.56%)发生出血,4例(11.11%)出现呼吸困难。结论:我院替格瑞洛多应用于对氯吡格雷低反应或其他抗血小板药物出现不良反应的急性冠脉综合征患者。临床药师应严格把握该药用法用量,密切监测患者不良反应,促进替格瑞洛的合理应用。
[Abstract]:Objective: To analyze the use of tigloria in hospitalized patients, to understand the clinical application status of the drug, and to provide reference for the improvement of the clinical rational use level of tegareo. Methods: From January to June,2014, the first hospital of Peking University was collected, and the patient's medical records were used to analyze the indications, usage, interaction and adverse reactions of the patients who used the tigloria. Results:36 patients,24 males and 12 females were included in the analysis, mean age (63.77 and 14.69), and body weight (70.76 to 11.17) kg. the original incidence is acute coronary syndrome, In 36 of the 36 patients,4 of the 36 patients were aspirin-combined with tigelorelle,30 were aspirin-combined with chlorofluorocarbon, and 1 case was aspirin-combined with silorello, and the other was replaced with tigrillo, and one case was aspirin, and the other 31 patients were treated with aspirin. The 5 patients used other different usage, as indicated in the instructions for use. There are 8 concomitant medications that may interact with tegrego. There were 6 cases of related adverse reactions, of which 2 (5.56%) had bleeding and 4 (11.11%) had difficulty breathing. Conclusion: The patients with acute coronary syndrome (ACS) with adverse reactions to the low-response or other anti-platelet drugs in the treatment of low-response or other anti-platelet drugs in our hospital. The clinical pharmacist should strictly control the dosage of the medicinal method, closely monitor the adverse reaction of the patient, and promote the rational application of tegareo.
【作者单位】：北京大学第一医院药剂科;安徽省立医院药剂科;
【分类号】：R969.3

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