135例醋酸去氨加压素注射剂不良反应分析

发布时间：2019-07-31 19:51

【摘要】：目的:分析醋酸去氨加压素注射剂不良反应的分布情况及发生特点,促进本品在临床中的合理使用。方法:采取回顾性研究的方法,对四川省药品不良反应监测中心2013年1月1日-2015年12月31日收集的135例醋酸去氨加压素注射剂不良反应/事件报告进行统计分析,探讨其不良反应发生的特征和规律。结果:从患者信息来看,醋酸去氨加压素注射剂引起的不良反应中中老年人患者居多;从用药情况来看,存在超说明书剂量和超说明书溶媒规定使用;从不良反应情况来看,63%发生在用药当日,不良反应表现主要涉及胃肠系统损害、中枢及外周神经系统损害、心血管系统损害,其中严重药品不良反应中60%发生用药后2 d及以上,不良反应表现主要为电解质异常导致的抽搐、意识障碍等。结论:临床上应关注使用醋酸去氨加压素注射剂时间过长致电解质异常的风险,避免超说明书用药,加强合理用药宣传,降低使用风险,减少不良反应的发生,进一步重视加强收集其导致电解质异常及其他的不良反应。
[Abstract]:Objective: to analyze the distribution and occurrence characteristics of adverse reactions of deaminopressin acetate injection, and to promote the rational use of this product in clinic. Methods: 135 cases of adverse reactions / event reports of deaminopressin acetate injection collected by Sichuan adverse Drug reaction Monitoring Center from January 1, 2013 to December 31, 2015 were statistically analyzed, and the characteristics and regularity of adverse reactions were discussed. Results: according to the patient information, most of the adverse reactions caused by deaminopressin acetate injection were in the middle and old age, and the dosage of hyperspecification and the solvent of hyperspecification were prescribed from the point of view of drug use. From the point of view of adverse reactions, 63% of the adverse reactions occurred on the day of medication. The adverse reactions mainly involved gastrointestinal system damage, central and peripheral nervous system damage, cardiovascular system damage. 60% of the serious adverse drug reactions occurred 2 days or more after treatment, and the adverse reactions were mainly convulsions caused by abnormal electrolytes, disturbance of consciousness and so on. Conclusion: attention should be paid to the risk of electrolyte abnormality caused by the use of deaminopressin acetate injection for too long, to avoid superspecification, to strengthen the propaganda of rational drug use, to reduce the risk of use, to reduce the occurrence of adverse reactions, and to pay more attention to the collection of electrolyte abnormalities and other adverse reactions.
【作者单位】：南充市药品不良反应监测中心;四川省药品不良反应监测中心;
【分类号】：R977

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