氟苯尼考磷脂复合物的制备及表征

发布时间：2019-08-26 14:28

【摘要】：目的氟苯尼考磷脂复合物的最佳工艺优化,并对其进行表征。方法以氟苯尼考与磷脂的复合率为评价指标,采用单因素试验和正交试验设计筛选最优制备工艺,考察了药物与磷脂的投料比、药物浓度、反应时间、反应温度这4个因素对磷脂复合物形成的影响,并利用UV、IR、显微镜等分析技术对复合物结构进行分析。结果确定氟苯尼考磷脂复合物的最佳制备工艺为:四氢呋喃为反应溶剂,药物与磷脂的比例为1:2,在45℃条件下反应2h,该工艺条件得到的磷脂复合物复合率为95%。结论 氟苯尼考磷脂复合物的形成受药物与磷脂的投料比、药物浓度以及反应时间的影响较大,反应温度也有一定的影响,且复合物在形成过程中并未发生化学变化,但与单纯的物理混合物有本质的区别。
[Abstract]:Objective to optimize the optimum process of florfenicol phospholipid complex and characterize it. Methods taking the compound rate of florfenicol and phospholipid as the evaluation index, the optimal preparation process was selected by single factor test and orthogonal test design. The effects of the ratio of drug to phospholipid, drug concentration, reaction time and reaction temperature on the formation of phospholipid complex were investigated, and the structure of the complex was analyzed by UV,IR, microscope. Results the optimum preparation process of florfenicol phospholipid complex was determined as follows: tetrahydrofuran was used as reaction solvent, the ratio of drug to phospholipid was 1 鈮，

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