萝卜硫烷对脑线粒体的影响：机理观点和未来发展方向（英文）
发布时间：2021-05-06 10:57
有机硫化物萝卜硫烷（SFN）是一种有效的细胞保护剂,在体外和体内实验模型中均可促进抗氧化、抗炎、抗糖化和抗菌作用。因为氧化磷酸化系统的存在,所以线粒体是三磷酸腺苷（ATP）的主要产生部位。同时,线粒体也是具核人体细胞中产生活性氧的主要场所。线粒体损伤在多种人类疾病中起着重要作用,包括神经退行性病变和代谢异常。本文描述和讨论了SFN调节哺乳动物细胞中线粒体功能和动力学的作用和机理,以及其对肿瘤细胞中线粒体促凋亡途径的促进作用。SFN对线粒体的调节作用使得它在一定程度上被认为是一种细胞保护剂。本文还指出了几个需要通过进一步实验解决的问题,即未来的可能研究方向,这可能会对该领域的研究人员具有指导作用。
【文章来源】：Journal of Zhejiang University-Science B（Biomedicine & Biotechnology）. 2020,21(04)SCICSCD
【文章页数】：17 页
【文章目录】：
1 Introduction
2 Overview of mitochondrial structure,func-tion,redox biology,and dynamics
3 Efects of SFN on brain mitochondria in in vitro experimental models
3.1 Mitochondria-related antioxidant and anti-apoptotic effects induced by SFN
3.2 Mitochondria-related anti-tumor effects in-duced by SFN
3.3 Effects of SFN on aspects related to mito-chondrial dynamics
4 Effects of SFN on brain mitochondria in in vivo experimental models
5 Conclusions and future directions
Contributors
Compliance with ethics guidelines
本文编号：3171802
【文章来源】：Journal of Zhejiang University-Science B（Biomedicine & Biotechnology）. 2020,21(04)SCICSCD
【文章页数】：17 页
【文章目录】：
1 Introduction
2 Overview of mitochondrial structure,func-tion,redox biology,and dynamics
3 Efects of SFN on brain mitochondria in in vitro experimental models
3.1 Mitochondria-related antioxidant and anti-apoptotic effects induced by SFN
3.2 Mitochondria-related anti-tumor effects in-duced by SFN
3.3 Effects of SFN on aspects related to mito-chondrial dynamics
4 Effects of SFN on brain mitochondria in in vivo experimental models
5 Conclusions and future directions
Contributors
Compliance with ethics guidelines
本文编号：3171802
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