改进的分散聚合法制备磁性高分子微球及其性能研究

发布时间：2018-03-08 11:12

本文选题：分散聚合法　切入点：磁性微球　出处：《华中科技大学》2011年硕士论文　论文类型：学位论文

【摘要】：由于磁性微球有很多其它物质不具备的特性,如表面效应,生物相容性,生化活性,磁效应,因而能在很多不同的领域中应用。比如在生物医药上就可以把磁性微球用于靶向给药,酶固定化等;在环境方面可用于污水处理,食品安全检测等。目前,国内外对磁性微球的研究都很热,现在已经能用多种方法制备出磁性微球并可以在临床上使用。本文用分散聚合法制备出多壳层的磁性微球,制备出的磁性微球分别用光学显微镜、荧光显微镜、扫描电镜、VSM等表征。结果表明其具有分散性好、粒径可调、磁性较强、超顺磁性、生物活性、生物相容性、在300°C下有很好的热稳定性等的特点。具体步骤是首先用分散聚合法制备了聚苯乙烯微球,再在其表面包覆一层SiO_2;用热分解法制备油相Fe_3O_4,并将其改性到水相中;最后用分散聚合法制备出磁性微球。本文还在磁性微球表面连上了亲和素和与抗体。
[Abstract]:Because the magnetic microspheres have many properties that other substances do not have, such as surface effects, biocompatibility, biochemical activities, magnetic effects, So it can be used in many different fields. For example, in biomedicine, magnetic microspheres can be used for targeted drug delivery, enzyme immobilization and so on. In environmental aspects, magnetic microspheres can be used for sewage treatment, food safety detection, etc. At present, The research on magnetic microspheres is very hot at home and abroad. Now, magnetic microspheres can be prepared by a variety of methods and can be used in clinic. In this paper, the multi-shell magnetic microspheres were prepared by dispersion polymerization. The magnetic microspheres were characterized by optical microscope, fluorescence microscope, scanning electron microscope and VSM respectively. The results showed that the magnetic microspheres had good dispersion, adjustable particle size and strong magnetic properties. Superparamagnetism, bioactivity, biocompatibility, excellent thermal stability at 300 掳C. Then a layer of Sio _ 2 was coated on the surface of Sio _ 2; oil phase Fe _ 3O _ 4 was prepared by thermal decomposition method and modified into water phase. Finally, magnetic microspheres were prepared by dispersion polymerization. The affinity and antibody were also attached to the surface of magnetic microspheres.
【学位授予单位】：华中科技大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：O631.5

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