微型化介质研磨法制备槲皮素纳米混悬剂

发布时间：2018-04-24 01:13

本文选题：槲皮素 + 纳米混悬剂　；参考：《中国中药杂志》2017年15期

【摘要】：采用Box-Behnken设计-效应面法优化一种微型化介质研磨法制备槲皮素纳米混悬剂(QT-NS)的工艺参数并评价所制得的QT-NS的体外累积释放度。结果显示,以最优工艺参数:氧化锆珠子4.5 m L、研磨速度690 r·min-1、研磨时间1.5 h,制得的QT-NS的粒径为(169±5)nm,多分散度指数为0.204±0.006,稳定系数为0.827±0.014,且理论预测值与实测值偏差较小,模型具有良好的预测性;在120 min体外累积释放度实验中,QT-NS明显高于原料药和物理混合物。使用该种微型化介质研磨法能成功制备QT-NS,且该方法中原料药消耗少,工艺简单、操作方便,可为纳米制剂的制备提供新的参考。
[Abstract]:The Box-Behnken design-effect surface method was used to optimize the preparation parameters of quercetin nano-suspension QT-NSs and to evaluate the cumulative release of the prepared QT-NS in vitro. The results show that with the optimum process parameters: zirconia beads 4.5 mL, grinding speed 690 r min -1, grinding time 1.5 h, the QT-NS particle size is 169 卤5 nm, the polydispersity index is 0.204 卤0.006, the stability coefficient is 0.827 卤0.014, and the deviation between the theoretical prediction value and the measured value is small. The model had good predictability and QT-NS was significantly higher than that of crude drug and physical mixture in the in vitro cumulative release test of 120 min. QT-NSs can be prepared successfully by using this miniaturized medium grinding method, and this method has the advantages of less consumption of raw materials, simple process and convenient operation, which can provide a new reference for the preparation of nanopharmaceuticals.
【作者单位】：成都中医药大学药学院;中国人民解放军空军总医院药学部;
【基金】：国家自然科学基金项目(81573697) 后勤科研重点项目(BKJ16J011)
【分类号】：R283.6

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