表面活性剂模板法制备纳米羟基磷灰石

发布时间：2018-05-14 09:09

本文选题：纳米羟基磷灰石 + 表面活性剂　；参考：《成都理工大学》2010年硕士论文

【摘要】： 羟基磷灰石是目前应用最为广泛的一类无机生物活性材料，在骨齿科临床修复中具有重要的应用价值。在人工合成羟基磷灰石的研究中，颗粒的尺寸、形貌以及表面状态对羟基磷灰石的应用性能有重要的影响。采用模板法制备羟基磷灰石纳米粉体，为实现颗粒尺寸、形貌及比表面积的控制提供了一种重要途径。本文采用溶致液晶模板法与反相微乳液法仿生合成了羟基磷灰石(HA)纳米粉体。通过透射电子显微镜(TEM)、X-射线衍射仪(XRD)、红外光谱仪(FTIR)等表征、测试手段研究了反应条件对产物结构和形貌的影响。绘制聚乙二醇辛基苯基醚(Triton X-100)-正奎醇-水体系局部相图，确定了层状液晶单相区。以聚乙二醇辛基苯基醚-正奎醇-水体系层状溶致液晶为模板，将硝酸钙和磷酸氢二铵分别溶于其溶剂层中，混合并经陈化，溶剂层中生成具有一定微观形貌的HA纳米粒子，直径为8～10nm，长度在100nm以下。讨论表面活性剂浓度、助表面活性剂浓度、反应物浓度、溶液pH值、陈化时间及热处理温度等因素对产物的形貌、结晶度等的影响。研究不同油相、不同比例聚乙二醇辛基苯基醚和正奎醇、不同反应物浓度对微乳液体系的影响，并绘制反相微乳液体系的三元局部相图；确定反相微乳液法制备纳米羟基磷灰石的最佳条件，，并以该反相微乳液为模板合成了梭状HA纳米颗粒。讨论了热处理温度、不同水油比以及陈化时间对HA纳米颗粒形貌、结晶程度等性质的影响，结果表明改变水油比可实现对纳米HA颗粒尺寸的控制。
[Abstract]:Hydroxyapatite is one of the most widely used inorganic bioactive materials. In the study of synthetic hydroxyapatite, the size, morphology and surface state of hydroxyapatite play an important role in the application performance of hydroxyapatite. Hydroxyapatite nano-powders were prepared by template method, which provides an important way to control particle size, morphology and specific surface area. Hydroxyapatite (HA) nano-powders were synthesized by lyotropic liquid crystal template method and inverse microemulsion method. The effects of reaction conditions on the structure and morphology of the products were investigated by means of transmission electron microscopy (TEM) and X-ray diffractometer (XRD), infrared spectroscopy (FTIR) and so on. The local phase diagram of poly (ethylene glycol octyl phenyl ether) Triton X-100 n-querenol-water system was drawn, and the single-phase region of lamellar liquid crystal was determined. The layered lyotropic liquid crystal (LLC) of polyethylene glycol octyl phenyl ether-n-querenol-water system was used as a template. Calcium nitrate and diammonium hydrogen phosphate were dissolved in their solvent layer respectively. After mixing and aging, HA nanoparticles with certain microscopic morphology were formed in the solvent layer. The diameter is 8 ~ 10 nm and the length is below 100nm. The effects of surfactant concentration, cosurfactant concentration, reactant concentration, pH value of solution, aging time and heat treatment temperature on the morphology and crystallinity of the product were discussed. The effects of different oil phase, different proportion of polyethylene glycol octyl phenyl ether and n-quinanol, different reactant concentration on the microemulsion system were studied, and the ternary local phase diagram of reverse microemulsion system was drawn. The optimum conditions for the preparation of nano-hydroxyapatite by inverse microemulsion method were determined, and the shuttled HA nanoparticles were synthesized by using the reverse microemulsion as template. The effects of heat treatment temperature, water / oil ratio and aging time on the morphology and crystallinity of HA nanoparticles were discussed. The results showed that the size of HA nanoparticles could be controlled by changing the ratio of water to oil.
【学位授予单位】：成都理工大学
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：TB383.1

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