静电纺丝法制备小口径胶原-聚乳酸人工血管

发布时间：2018-05-15 08:20

本文选题：聚乳酸 + 胶原　；参考：《复合材料学报》2017年11期

【摘要】：以聚乳酸(PLA)和胶原(Col)为原料,通过静电纺丝法制备了小口径(d=3.0mm)Col-PLA人工血管。采用扫描电镜、孔径分析仪和万能拉力机对Col-PLA人工血管的外层纤维形貌、孔径和拉伸性能进行了表征,测定了人工血管的管壁厚度及爆破强度。研究了纺丝电压、纺丝液质量分数、PLA与Col质量比对人工血管结构及性能的影响。结果表明:随纺丝电压的增加,纤维排列由杂乱变为规整,最佳的纺丝电压为15~20kV之间;当纺丝液质量分数增大时,Col-PLA人工血管的纤维直径增大,孔径及孔隙率均变小,拉伸强度和爆破强度提高;随PLA与Col质量比提高,人工血管的内层管壁厚度减少,外层管壁厚度增加,使拉伸强度和爆破强度提高,PLA与Col质量比分别为70∶30和90∶10时,制得人工血管力学强度能够满足使用要求。
[Abstract]:Col-PLA artificial blood vessels were prepared by electrospinning with polylactic acid (PLA) and collagen (Coll) as raw materials. The morphology, pore diameter and tensile properties of the outer layer of Col-PLA artificial blood vessel were characterized by scanning electron microscope, aperture analyzer and universal tension machine. The wall thickness and blasting strength of the artificial vessel were measured. The effects of spinning voltage and the mass ratio of PLA to Col on the structure and properties of artificial blood vessels were studied. The results showed that with the increase of spinning voltage, the fiber arrangement changed from clutter to regularity, and the optimum spinning voltage was between 15~20kV, and the diameter of fiber and pore size and porosity of Col-PLA artificial blood vessel increased with the increase of spinning solution mass fraction. With the increase of the mass ratio of PLA to Col, the thickness of the inner wall of the artificial blood vessel decreases and the thickness of the outer wall increases, which makes the tensile strength and the blasting strength of the artificial blood vessel increase when the mass ratio of Col to Col is 70:30 and 90:10, respectively. The mechanical strength of artificial blood vessel can meet the requirement of application.
【作者单位】：山东省药学科学院山东省医用高分子材料重点实验室;
【基金】：山东省重点研发计划(2015GSF118089)
【分类号】：R318.08

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