共聚法制备骨架温敏超支化聚酰胺类分子及其离子响应的研究

发布时间：2018-05-24 10:12

本文选题：超支化聚合物 + 刺激响应性　；参考：《河北大学》2017年硕士论文

【摘要】：骨架响应性超支化聚合物凭借可调控的树枝状拓扑结构和骨架刺激响应性两大特点,能够以单分子或者组装体形式对客体分子如药物、催化剂、离子等进行负载,并且能够利用其刺激响应性将客体分子释放或者连同客体分子一起与体系分离,表现出巨大的研究价值和应用前景。本文通过可逆加成断裂链转移聚合法制备超支化亚甲基双丙烯酰胺/乙二胺双丙烯酰胺共聚物(HCPAM)。通过浊度分析证明了其骨架温敏性,讨论了单体配比对聚合物临界相转变温度(LCST)的影响。此外,作为潜在的药物载体,HCPAM的LCST可能受到体内离子的影响。因此,本文还研究了几种常见金属离子对HCPAM溶液呈现的离子特异性效应,并采用红外光谱分析法对其离子效应机理进行了证明。本论文共分三章,其主要内容如下:第1章:绪论。简单介绍了刺激响应性超支化聚合物的发展现状和聚合物的离子特异性效应的相关内容,并详述了论文的设计思路与意义。第2章:链转移剂(CTA)和单体的制备、纯化及表征,超支化聚亚甲基双丙烯酰胺/乙二胺双丙烯酰胺共聚物的制备及结构表征,相转变温度的调节以及相变过程的研究。第3章:不同离子不同浓度对HCPAM的LCST的影响,得出相应的离子序列,解释了离子特异性效应的机理。
[Abstract]:Skeleton responsive hyperbranched polymers are capable of loading guest molecules such as drugs, catalysts, ions and so on in the form of monolayers or assemblies by virtue of their controllable dendritic topology and skeleton stimulus response. And it can release the guest molecule or separate the guest molecule from the system with its stimulus response, which shows great research value and application prospect. In this paper, hyperbranched methylene bisacrylamide / ethylenediamine diacrylamide copolymer (HCPAM) was prepared by reversible addition chain transfer polymerization. The temperature sensitivity of the polymer skeleton was proved by turbidity analysis, and the influence of monomer ratio on the critical phase transition temperature (LCSTT) of polymer was discussed. In addition, LCST, as a potential drug carrier, may be affected by ions in vivo. Therefore, the ion-specific effect of several common metal ions on HCPAM solution was also studied, and the mechanism of ion effect was proved by infrared spectroscopy. This paper is divided into three chapters, the main contents are as follows: chapter 1: introduction. This paper briefly introduces the development of stimulation-responsive hyperbranched polymers and the related contents of ionic specificity of polymers, and details the design ideas and significance of this paper. Chapter 2: preparation, purification and characterization of chain transfer agent (CTAA) and monomer, preparation and structure characterization of hyperbranched polymethylene bisacrylamide / ethylenediamine bisacrylamide copolymer, adjustment of phase transition temperature and study of phase transition process. Chapter 3: the effect of different ion concentration on LCST of HCPAM was studied. The corresponding ion sequence was obtained and the mechanism of ion specificity was explained.
【学位授予单位】：河北大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：O633.22

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