微型化介质研磨法制备难溶性黄酮类化合物纳米混悬剂

发布时间：2018-06-01 22:49

本文选题：微型化介质研磨法 + 纳米混悬剂　；参考：《中草药》2017年21期

【摘要】：目的探讨微型化介质研磨法制备难溶性黄酮类化合物纳米混悬剂(NS)的可行性。方法以磁力搅拌器为动力装置,西林瓶为研磨室,采用氧化锆珠子为研磨介质构建微型化介质研磨法制备槲皮素(QCT)、黄芩苷(BCN)、葛根素(PRN)及水飞蓟素(SLR)4种黄酮类化合物NS,以平均粒径、多分散度指数(PDI)和稳定性指数(SI)为指标,对工艺参数转速、研磨介质用量和研磨时间进行优化。结果 QCT-NS、BCN-NS、PRN-NS和SLR-NS制备的最佳工艺参数转速、研磨时间、氧化锆用量与药物混悬液比例分别为QCT-NS 800 r/min、8 h、1∶1,BCN-NS 800 r/min、24 h、1∶1,PRN-NS800 r/min、24 h、2∶1,SLR-NS 800 r/min、12 h、1∶1;以最佳工艺参数制备所得QCT-NS、BCN-NS、PRN-NS和SLR-NS的平均粒径均在400 nm以下,QCT-NS、BCN-NS和SLR-NS的PDI在0.3以下,SI高于0.75;PRN-NS的PDI和SI分别为0.41和0。结论微型化介质研磨法制备难溶性黄酮类化合物NS工艺简单、稳定可行,值得进一步深入研究。
[Abstract]:Objective to investigate the feasibility of preparation of refractory flavonoids nano suspension (NS) by micro medium grinding method. Methods the magnetic agitator was used as the power device, the Silin bottle was used as the grinding room, and the zirconium oxide beads were used as the grinding medium to prepare quercetin (QCT), baicalin (BCN), Ge Gensu (PRN) and silymarin (SLR). 4 flavone compounds NS, with the average particle size, the polydispersity index (PDI) and the stability index (SI) as the index, the process parameters speed, the grinding medium dosage and the grinding time are optimized. Results the optimum technological parameters of QCT-NS, BCN-NS, PRN-NS and SLR-NS are the optimum technological parameters, the grinding time, the dosage of zirconium oxide and the proportion of drug suspension are QCT-, respectively. NS 800 r/min, 8 h, 1: 1, BCN-NS 800 r/min, 24 h, 1: 1, PRN-NS800 r/min, 24 h, 2: 1, SLR-NS 800 r/min, 12 h, 1: The preparation of insoluble flavonoids NS by the micro medium grinding method is simple, stable and feasible. It is worth further studying.
【作者单位】：江西中医药大学现代中药制剂教育部重点实验室;中国人民解放军空军总医院药学部;
【基金】：国家自然科学基金资助项目(81573697) 后勤科研重点项目(BKJ16J025,BKJ16J011)
【分类号】：R283.6

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