层层自组装法制备百里香精油微胶囊条件优化
发布时间：2018-12-16 05:39
【摘要】：采用层层自组装的方法,以百里香精油乳化液纳米微粒作为核心,利用壳聚糖和海藻酸钠对百里香精油进行包埋;以司盘80和吐温60复配乳化剂亲水亲油平衡(hydrophilic lipophilic balance,HLB)值、用量及油乳比例3个因素进行实验,确定乳化液最适制备条件;以壁材溶液质量浓度、组装层数、每层组装时间、搅拌速率、组装温度、壁材溶液pH值和固化剂用量进行单因素试验,以主要因素设计正交试验,确定最佳包埋条件。结果表明,乳化液制备条件为HLB值10、乳化剂用量6%、精油与乳化剂体积比1∶6,此条件下所制备的乳化微粒为模板,组装层数4层、搅拌速率1 040 r/min、每层组装时间15 min、壁材溶液pH 5.0、组装温度30℃,此条件下包埋率最高为80.23%。
[Abstract]:The thyme essential oil was encapsulated by chitosan and sodium alginate by the method of layer-by-layer self-assembly with thyme essential oil emulsions as the core and chitosan and sodium alginate as the core. The optimum preparation conditions of emulsion were determined by using three factors, such as the (hydrophilic lipophilic balance,HLB value of hydrophilic and lipophilic equilibrium, the amount of emulsifier and the proportion of oil emulsion, which were mixed with Span 80 and Twain 60. The single factor experiment was carried out with the mass concentration of the wall solution, the number of the assembled layers, the assembling time of each layer, the stirring rate, the assembly temperature, the pH value of the wall material solution and the amount of curing agent. The orthogonal test was designed with the main factors to determine the optimal embedding conditions. The results showed that the preparation conditions of emulsion were as follows: HLB value 10, emulsifier dosage 6, volume ratio of essential oil to emulsifier 1: 6. The emulsified particles prepared under this condition were template, four layers of assembly layer, and stirring rate of 1 040 rmin. The composition time of each layer is 15 min, the solution pH is 5.0, and the assembly temperature is 30 鈩，
本文编号：2381893
[Abstract]:The thyme essential oil was encapsulated by chitosan and sodium alginate by the method of layer-by-layer self-assembly with thyme essential oil emulsions as the core and chitosan and sodium alginate as the core. The optimum preparation conditions of emulsion were determined by using three factors, such as the (hydrophilic lipophilic balance,HLB value of hydrophilic and lipophilic equilibrium, the amount of emulsifier and the proportion of oil emulsion, which were mixed with Span 80 and Twain 60. The single factor experiment was carried out with the mass concentration of the wall solution, the number of the assembled layers, the assembling time of each layer, the stirring rate, the assembly temperature, the pH value of the wall material solution and the amount of curing agent. The orthogonal test was designed with the main factors to determine the optimal embedding conditions. The results showed that the preparation conditions of emulsion were as follows: HLB value 10, emulsifier dosage 6, volume ratio of essential oil to emulsifier 1: 6. The emulsified particles prepared under this condition were template, four layers of assembly layer, and stirring rate of 1 040 rmin. The composition time of each layer is 15 min, the solution pH is 5.0, and the assembly temperature is 30 鈩，
本文编号：2381893
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