碳酸钙模板法制备高分子微球

发布时间：2019-03-12 10:37

【摘要】：模板法是一种制备粒径可控、形貌均一微球的有效途径。以球霰石形态存在的CaCO_3多孔微球具有生物相容、孔径均一,以及可在温和条件下分解等优点,适用于作为模板制备微球。本文在对CaCO_3模板进行简单介绍的基础上,从原料选取与应用角度综述了用CaCO_3模板法制备微球的研究进展。常用的装载CaCO3多孔微球的方法有物理吸附、共沉淀和渗透法等,所用原料有天然高分子(如多糖、蛋白质、DNA)和合成高分子(如聚苯乙烯磺酸钠、聚乙烯醇)。利用CaCO_3模版制备的微球具有多孔洞或空心结构,尺寸形貌均一可控,特别适用于制药、药物递送、生物传感器及化学分析等领域。预计随着纳米技术的发展和生物医药领域的需求将推动CaCO_3模板法的研究,以期通过该方法制备出应用领域更加广泛的微球。
[Abstract]:The template method is an effective way to prepare a microsphere with controllable particle size and morphology. The CaCO _ 3 porous microspheres, which are present in the form of a ball and stone, have the advantages of being biocompatible, uniform in pore size, and capable of being decomposed under mild conditions and the like, and is suitable for preparing microspheres as templates. In this paper, based on the simple introduction of the CaCO _ 3 template, the research progress of the preparation of the microspheres with the CaCO _ 3 template method is reviewed from the selection and application of the raw materials. The commonly used methods for loading CaCO3 porous microspheres include physical adsorption, co-precipitation and infiltration. The raw materials used are natural polymers (such as polysaccharides, proteins, DNA) and synthetic polymers (such as sodium polystyrene sulfonate and polyvinyl alcohol). The microsphere prepared by using the CaCO3 template has a multi-hole or a hollow structure, and the size and the appearance are all controllable, and is particularly suitable for the fields of pharmacy, drug delivery, biological sensor and chemical analysis and the like. It is expected that with the development of the nano-technology and the demand of the bio-medicine field, the study of the CaCO3 template method will be promoted, with a view to preparing the microspheres with a wider application field through the method.
【作者单位】：西北师范大学化学化工学院生态环境相关高分子材料教育部重点实验室;
【基金】：国家自然科学基金项目(No.21263024,21364012)资助~~
【分类号】：TQ317

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