用药动作线索诱发海洛因戒断者的镜像神经活动:一项fMRI研究

发布时间：2018-01-26 04:54

本文关键词： 心理渴求镜像神经具身认知　出处：《心理学报》2016年12期 　论文类型：期刊论文

【摘要】：相关线索能够诱发药物依赖者的心理渴求,而健康人不会对相关线索产生心理渴求。15名海洛因成瘾者和12名没有任何物质滥用的健康被试参与实验,收集了他们在观看相关线索与对照线索时的脑神经活动。结果发现,药物线索能够诱发戒断者更多脑区的活动,包括扣带回和楔前叶。两组被试在对照动作线索刺激诱发作用下,其颞叶、顶叶均出现了较为一致的活动。在用药动作线索诱发作用下,戒断组双侧颞中回、双侧顶下小叶、左侧顶上小叶和右侧额下回显示出显著活动,并且与对照动作线索激活脑区一致;健康组被试除枕叶-颞叶联合区外,没有出现显著的脑区活动。以上结果表明,用药动作线索诱发了海洛因戒断者颞中回、顶下小叶、额下回等镜像神经系统的活动,这些脑区对不同类型的相关线索十分敏感,它们可能通过对用药动作的心理模拟,参与了用药动作线索的快速自动化加工。
[Abstract]:Related clues could induce psychological craving of drug addicts, while healthy people did not develop psychological craving for related clues. 15 heroin addicts and 12 healthy subjects without any substance abuse participated in the experiment. The results showed that drug cues could induce more brain activity in abstinents. The temporal lobe and parietal lobe of the two groups showed consistent activities under the stimulation of control action cues. Under the action of the action cues of medication, the middle temporal gyrus of both sides in the abstinence group was induced. Bilateral inferior parietal lobules, left superior parietal lobules and right inferior frontal gyrus showed significant activity, which was consistent with the activation of brain regions by action cues. There was no significant brain activity except occipital lobe-temporal lobe in healthy subjects. The results showed that the action cues induced the middle temporal gyrus and inferior parietal lobule in heroin abstinents. The activities of mirror nervous system such as inferior frontal gyrus, these brain regions are very sensitive to different types of related cues, they may participate in the rapid automatic processing of drug action cues through psychological simulation of drug use actions.
【作者单位】：广州大学心理系;广州大学心理与脑科学研究中心;华南师范大学心理学院;
【基金】：国家自然科学基金(31271113)资助
【分类号】：B845.1
【正文快照】： 1问题的提出精神活性物质能够直接或间接地引起纹状体(包括伏隔核)的多巴胺(Dopamine,DA)浓度增加,产生用药后的急性反应,给用药者带来欣快感(Koob,1992),使用药者对精神活性物质逐渐产生依赖。精神活性物质对于依赖者来说是非条件刺激,药物依赖者重复用药,在条件(conditionin

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