社会隔离与同伴状态对青春期大鼠吗啡行为敏感化及新颖环境偏爱的影响

发布时间：2018-03-29 22:05

本文选题：社会隔离　切入点：青春期　出处：《首都师范大学》2014年硕士论文

【摘要】：社会环境是影响青春期动物药物成瘾易感性的重要因素之一,社会环境的这种影响包括社会隔离和同伴关系等因素。有关研究发现,与药物成瘾有关的新颖寻求行为也在一定程度受社会环境影响,而新颖寻求也影响药物成瘾。本研究主要考察在社会隔离及群组情境下不同药物处理同伴对青春期大鼠吗啡行为敏感化的影响及其与新颖寻求水平可能存在的关系。本实验选用72只青春期Sprague-Dawley大鼠(3周龄),共分为6个组：单独饲养的吗啡处理组和盐水处理组、两只共同饲养的吗啡处理组、两只共同饲养的盐水处理组、两只不同处理混合饲养组中的吗啡组以及盐水组。在8天的适应饲养后,按照分组对动物进行吗啡(5mg/kg)或盐水处理7天,经过7天的戒断期之后进行行为敏感化测试,在戒断期的最后3天进行新颖环境偏爱测试。实验结果显示：群组饲养的大鼠的同伴是否接受药物处理对动物自身的吗啡成瘾无影响；社会隔离饲养使吗啡慢性处理导致的青春期大鼠行为敏感化水平提高；而社会隔离和同伴药物状态只对盐水处理组大鼠的新颖环境偏爱有影响。社会隔离对青春期大鼠的新颖环境偏爱水平和吗啡行为敏感化的影响并不是完全一致的。研究结果表明社会环境中同伴的存在对环境线索刺激及药物刺激引起的吗啡复吸具有预防作用。这种社会环境对药物成瘾的影响与对新颖寻求的影响可能并不涉及共同的机制。
[Abstract]:Social environment is one of the important factors that influence the susceptibility of adolescent animals to drug addiction. This influence of social environment includes social isolation and peer relationship. Novel seeking behaviors related to drug addiction are also affected to some extent by the social environment, This study investigated the effects of different drug treatment peers on morphine behavior sensitivity in adolescent rats under social isolation and group situations and the possible relationship between novel seeking level and novel seeking level. Seventy-two pubertal Sprague-Dawley rats were divided into 6 groups: morphine treated group and saline group, morphine treated group and saline treated group. After 8 days of adaptation, animals were treated with morphine (5 mg / kg) or saline for 7 days. After 7 days of withdrawal, behavioral sensitivities were tested. Novel environmental preference tests were performed on the last 3 days of the withdrawal period. The results showed that whether the cohort rats were treated with drugs or not had no effect on the morphine addiction of the animals themselves, and that the social isolation raised the behavioral sensitivity of the adolescent rats induced by chronic morphine treatment. However, social isolation and peer drug status had only effects on the novel environmental preference of saline treated rats, and the effects of social isolation on the level of novel environmental preference of adolescent rats were not consistent with those of morphine behavioral sensitivity. The results show that the presence of peers in the social environment can prevent morphine relapse induced by environmental cues and drug stimuli. The effects of this social environment on drug addiction and novel search may not be significant. Involving common mechanisms.
【学位授予单位】：首都师范大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：B845

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