拖延的认知神经机制与基因:行为-脑-基因的多角度研究

发布时间：2018-05-13 11:40

本文选题：拖延行为 + 多模态技术　；参考：《心理科学进展》2017年03期

【摘要】：拖延是一种普遍存在,具有跨时间和跨情景稳定性的问题行为,严重的拖延甚至会危害到人们的工作、学习及身心健康。鉴于目前对于拖延的认知神经机制仍不清楚,研究模态较为单一,本研究拟从行为-脑-基因的系统研究思路出发,以多模态MRI(Task、Resting、VBM和DTI)为主要技术手段,将HTR2B基因多态性作为突破口,系统考察拖延的认知机制、神经基础和遗传基础,并试图制定拖延的应对与干预方案。研究分为4个部分:(1)从行为上,结合预期恐惧范式和跨期选择范式探索其拖延决策的机制;(2)在神经层面上,采用MRI多模态技术系统考察拖延行为的神经基础;(3)在基因层面上,采用分子遗传学方法,将HTR2B设定为靶基因以深入研究拖延的遗传基础,并考察脑结构和脑功能在基因与行为间的中介作用;(4)最后从行为干预与脑的可塑性的角度,设计拖延的干预方法来改善拖延行为并验证拖延的神经机制。
[Abstract]:Procrastination is a common problem behavior with cross-temporal and cross-situational stability. Serious procrastination may even harm people's work, study and physical and mental health. In view of the fact that the cognitive neural mechanism of procrastination is still unclear and the mode of study is relatively simple, this study intends to proceed from the systematic study of behavior-brain-gene, using multimodal MRI- Task-Restingningen VBM and DTI as the main technical means. Taking the polymorphism of HTR2B gene as the breakthrough point, the cognitive mechanism, neural basis and genetic basis of procrastination were systematically investigated, and the coping and intervention schemes of procrastination were tried to be worked out. The study is divided into four parts: 1) from the behavior perspective, combining the expected fear paradigm and the intertemporal selection paradigm to explore the mechanism of procrastination decision making. On the neural level, the neural basis of procrastination behavior is systematically investigated by using the MRI multi-modal technique) at the genetic level. In order to study the genetic basis of procrastination, the molecular genetics method was used to set HTR2B as a target gene, and the interplay of brain structure and brain function between gene and behavior was investigated. Finally, from the perspective of behavioral intervention and brain plasticity, Procrastination intervention was designed to improve procrastination and verify the neural mechanism of procrastination.
【作者单位】：西南大学心理学与社会发展研究中心心理学部;
【基金】：国家自然科学基金面上项目(31271117,31571128) 重庆市人文社会科学重点研究基地重点项目(16SKB007) 中央高校基本科研业务经费创新团队项目(SWU1509392)资助
【分类号】：B845.1

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