MAOA基因rs6323多态性与同伴关系对男青少年早期抑郁的影响

发布时间：2018-09-01 15:06

【摘要】：以683名男青少年为被试(初次测评时M=13.35岁;SD=0.51),综合运用传统回归分析和新兴显著性区域检验,考察了MAOA基因rs6323多态性与同伴关系对青少年早期抑郁的交互作用及其表现形式。结果表明:当同伴接纳水平较低时,G等位基因携带者的抑郁水平表现出高于T等位基因携带者的趋势,当同伴接纳水平较高时,G型基因携带者的抑郁水平显著低于T等位基因携带者;同伴接纳可以显著预测G等位基因携带者的抑郁,但对T等位基因携带者的抑郁无显著预测作用;rs6323多态性与同伴拒绝的交互作用亦不显著。研究结果提示,同伴关系对MAOA基因与男青少年早期抑郁的关联起调节作用,且其作用形式部分支持不同易感性模型观点。
[Abstract]:The interaction between MAOA gene rs6323 polymorphism and peer relationship on early depression was investigated in 683 male adolescents (MJ 13.35 years old SDX 0.51) by using traditional regression analysis and new significant region test. The results showed that the depression level of G allele carriers was higher than that of T allele carriers when the peer acceptance level was low. The depression level of G type carriers was significantly lower than that of T allele carriers when the level of peer acceptance was higher, and peer acceptance could significantly predict the depression of G allele carriers. However, there was no significant predictive effect on depression in T allele carriers. The interaction between rs6323 polymorphism and peer rejection was not significant. The results suggest that peer relationship regulates the association of MAOA gene with early depression in male adolescents, and its form of action partly supports the view of different susceptibility models.
【作者单位】：山东师范大学心理学院;
【基金】：国家自然科学基金项目(31271105) 2013年度高等学校博士学科点专项科研基金项目(博导类20133704110001) 山东省优秀中青年科学家奖励基金项目(BS2013SF010) 山东省“十二五”强化建设重点学科(发展与教育心理学)建设经费资助项目山东师范大学优秀青年骨干教师国际合作(学科带头人培育)计划项目山东师范大学心理学院青年教师研究创新计划项目资助
【分类号】：B844.2

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