南海地区115例登革热患者实验室检查结果分析

发布时间：2018-01-18 11:18

本文关键词：南海地区115例登革热患者实验室检查结果分析　出处：《实验与检验医学》2016年03期 　论文类型：期刊论文

【摘要】：目的分析2014年6月-2015年10月南海经济开发区人民医院115例登革热住院患者实验室检查结果的特点,为临床治疗、检验标准的制定提供依据及意见。方法采用迈瑞BC 5800全自动血细胞分析仪检测白细胞(WBC)、血小板(PLT);采用奥林巴斯AU-640全自动生化分析仪检测丙氨酸氨基转移酶(ALT)、肌酐(Cr);采用Sysmex CA-530全自动凝血分析仪检测活化部分凝血酶时间(APTT);采用ELISA双抗体夹心法检测登革热NS1抗原。以符合重症登革热预警指征(DWS)者为预警组(WS),无DWS者为普通组(DF),分析两组之间各实验室检查结果的差异。结果实验室结果为:WBC减少81例(70.4%),PLT减少103例(89.6%),ALT升高55例(47.8%),APTT延长68例(59.1%),Crea升高14例(12.1%)。WS组的WBC、ALT结果与DF组无明显差异(P0.05),WS组的APTT、Cr结果显著高于DF组(P0.05)。结论大多数登革热患者WBC、PLT减少明显;近半数合并肝脏损害;超半数患者出现内源性凝血系统异常,符合DWS患者可存在更严重的内源性凝血系统异常,对预防普通病例发展为重症登革热(SD)和救治重症患者有参考意义。仅少数病人出现肾脏损害,但符合DWS患者肾功能受到的影响比普通登革热患者大。
[Abstract]:Objective to analyze the laboratory results of 115 patients with dengue fever from June 2014 to October 2015 in the people's Hospital of South China Sea Economic Development Zone. Methods WBC 5800 automatic blood cell analyzer was used to detect WBCX and PLT. AU-640 automatic biochemistry analyzer was used to detect alanine aminotransferase (alt) and creatinine (Cr). The activated partial thrombin time was detected by Sysmex CA-530 automatic coagulation analyzer. ELISA double antibody sandwich method was used to detect NS1 antigen of dengue fever. The differences of laboratory results between the two groups were analyzed. The results were as follows: 81 cases of WBC were reduced by 70.4 cases and 103 cases of PLT were decreased in 103 cases (89.6%). ALT was increased in 55 cases (47.8%) and prolonged in 68 cases (59. 1%). 14 cases (14 cases) increased crea. WBC in WS group. There was no significant difference between the results of ALT and that of DF group. The results of ALT in WS group were significantly higher than those in DF group. Conclusion most patients with dengue fever have WBC. PLT decreased significantly; Nearly half of them were complicated with liver damage. More than half of the patients had abnormal endogenous coagulation system, which could be more serious in patients with DWS. Only a few of the patients had renal damage, but the renal function of the patients with DWS was more affected than that of the patients with dengue fever.
【作者单位】：南海经济开发区人民医院检验科;南海经济开发区人民医院内科;
【分类号】：R512.8;R446.6
【正文快照】： 登革热是由登革热病毒(DENV)感染引起的急性传染病,主要临床特点为发热、头痛、全身肌肉关节疼痛、乏力、皮疹、出血倾向、淋巴结肿大、白细胞和血小板减少等,我国《登革热诊疗指南》(2014年第2版)[1]将其分为普通登革热(DF)和重症登革热(SD)两种临床类型,其中DF可伴/不伴重症

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