果糖注射液对慢性乙型肝炎合并2型糖尿病患者的安全性分析

发布时间：2018-01-20 07:39

本文关键词： 果糖注射液慢性乙型肝炎型糖尿病肌酐尿素氮尿酸　出处：《重庆医科大学学报》2017年07期 　论文类型：期刊论文

【摘要】：目的:评价果糖注射液用于慢性乙型肝炎(chronic hepatitis B,CHB)合并2型糖尿病(type 2 diabetes,T2DM)的患者血肌酐、尿素氮及血尿酸的影响。方法:71例CHB合并T2DM患者随机分为对照组(38例)和实验组(33例)。对照组患者以250m L的5%葡萄糖注射液加入3 U胰岛素作为异甘草酸镁注射液或甘草酸二铵注射液的溶媒静脉滴注,实验组患者以250 m L的10%果糖注射液作为异甘草酸镁注射液或甘草酸二铵注射液的溶媒静脉滴注。监测第1天和第5天患者血肌酐、尿素氮及血尿酸水平,同时监测患者血、尿常规、电解质浓度及酸碱平衡、心电图乳酸、动脉血p H值。结果:干预后实验组和对照组疗效之差的双侧90%置信区间结果为血肌酐(-6.94,6.58)和血尿酸(-50.81,36.29)的置信区间上下限在其等效性界值置信区间(-△,△)范围内,表明实验组和对照组疗效相等,尿素氮实验组和对照组疗效之差置信区间下限(-0.38)大于-△(-0.86),提示实验组疗效非劣于对照组的疗效,但不能得出其等效性结论。无其他相关不良反应的发生。结论:果糖注射液对CHB合并T2DM患者的血肌酐、尿素氮及血尿酸无影响,果糖注射液作为甘草酸类制剂的溶媒输液用于CHB合并T2DM患者安全可靠。
[Abstract]:Objective: to evaluate the effect of fructose injection on type 2 diabetes mellitus (type 2) in patients with chronic hepatitis B (hepatitis). Serum creatinine in patients with T2DM. Effect of urea nitrogen and uric acid. Methods 71 cases of CHB with T2DM were randomly divided into control group (n = 38) and experimental group (n = 33). Patients in control group were treated with 250ml 5% glucose injection and 3 U insulin as solvent intravenous drip of magnesium isoglycyrrhizinate injection or diammonium glycyrrhizinate injection. 10% fructose injection (250ml) was used as the solution of magnesium isoglycyrrhizinate injection or diammonium glycyrrhizinate injection. The serum creatinine was monitored on the 1st and 5th day. The levels of urea nitrogen and uric acid, blood and urine routine, electrolyte concentration and acid-base balance, electrocardiogram lactic acid were monitored at the same time. Results: the 90% confidence interval of the difference of therapeutic effect between the experimental group and the control group was found to be serum creatinine creatinine (-6.94 卤6.58) and serum uric acid (-50.81) after intervention. 36.29) the upper and lower limits of the confidence interval are within the range of the confidence interval of its equivalence value, which indicates that the efficacy of the experimental group and the control group is equal. The lower confidence interval of urea nitrogen test group and control group was greater than that of-0.86, indicating that the effect of the experimental group was not inferior to that of the control group. Conclusion: fructose injection has no effect on serum creatinine, urea nitrogen and uric acid in CHB patients with T2DM. Fructose injection as a solvent infusion of glycyrrhizic acid for CHB patients with type 2 DM is safe and reliable.
【作者单位】：福建医科大学孟超肝胆医院感染科;
【基金】：福州市临床重点专科感染病科建设资助项目(编号:201510301)
【分类号】：R512.62;R587.1
【正文快照】： 成人慢性乙型肝炎(chronic hepatitis B,CHB)患者中2型糖尿病(type 2 diabetes,T2DM)发病率为25%[1],为普通人群的4倍,CHB合并T2DM患者的血糖调节能力显著降低,肝糖原的合成和糖原的异生能力也明显减弱,血糖波动比较明显,同时糖尿病的存在也与CHB患者肝病的发病率和死亡率相关

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