2013年新疆436例不同民族住院结核病患者的耐药情况分析

发布时间：2018-01-20 09:55

本文关键词： 结核病结核分枝杆菌耐药民族　出处：《中华疾病控制杂志》2015年07期 　论文类型：期刊论文

【摘要】：目的了解住院结核病患者的耐药情况,为制定合理的治疗方案提供依据。方法分析2013年1月~12月新疆维吾尔自治区胸科医院住院耐药结核病患者的耐药情况。结果 436例耐药结核病患者中对抗结核药物耐药率前4位从高到低依次异烟肼(65.5%)、链霉素(56.4%)、利福平(53.9%)、利福布丁(40.6%);复治结核病患者对利福平、异烟肼、利福布丁、氧氟沙星、左氧氟沙星、环丙沙星的耐药率高于初治患者高;初治患者中单耐药构成比最大,为49.5%,复治患者中耐多药构成最大,占50.4%;不同民族结核病患者对利福布丁、吡嗪酰胺、利福喷丁、阿米卡星单种抗结核药物耐药率差异均有统计学意义(均有P0.05),利福布丁在哈萨克族中耐药率最高,有33例,占60.0%;学生、干部患者单耐药较多,分别占50.0%,47.6%,待业及自由职业者中耐多药比例较高,占52.1%。既往结核治疗中有间断患者中耐多药比例比无间断患者大,分别占55.4%,44.6%。结论本次住院结核病患者结核分枝杆菌耐药以耐异烟肼、利福平最常见,复治患者耐多药率较高。
[Abstract]:Objective to investigate the drug resistance of inpatients with tuberculosis. Methods from January 2013 to December, the drug resistance of drug-resistant tuberculosis patients in Xinjiang Uygur Autonomous region chest Hospital was analyzed. In 436 drug-resistant TB patients, isoniazid ranked first 4 from high to low. 65.5). Streptomycin 56.4, rifampicin 53.9, rifampicin 40.6; The drug resistance rates of patients with recurrent tuberculosis to rifampicin, isoniazid, rifambutin, ofloxacin, levofloxacin and ciprofloxacin were higher than those of the first treated patients. The ratio of single drug resistance to single drug resistance was the largest (49.5%) in the first treatment patients, and the multidrug resistance component was the largest (50.4%) in the patients with re-treatment. The drug resistance rates of rifambutin, pyrazinamide, rifampicin and amikacin in tuberculosis patients of different nationalities were significantly different (all P 0.05). The drug resistance rate of rifampicin was the highest in Kazak nationality, 33 cases (60.0%); Students and cadres had more single drug resistance, accounting for 50. 0% and 47. 6% respectively. The proportion of multi-drug resistance in unemployed and freelance workers was higher. The proportion of multidrug resistance in patients with previous tuberculosis treatment was higher than that in patients without interruption, accounting for 55.4%, respectively. Conclusion the resistance of Mycobacterium tuberculosis to isoniazid and rifampicin is the most common, and the rate of multidrug resistance in patients with recurrent tuberculosis is higher.
【作者单位】：新疆医科大学公共卫生学院流行病与卫生统计学教研室;新疆自治区胸科医院;
【基金】：新疆自治区高技术研究发展计划(201417104)
【分类号】：R52
【正文快照】： (Chin J Dis Control Prev 2015,19(7):675-678)结核病及其危险因素。结核病是严重危害人类健康的我国重点控制的重大传染病之一,耐药结核分枝杆菌菌株的出现并流行成为全球关注的问题。耐药结核病不仅治疗周期长,药物副作用大,而且治疗效果差,治愈率低,病死率高;耐多药结核病

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