副肿瘤性边缘性脑炎13例分析并文献复习

发布时间：2018-01-29 20:10

本文关键词： PLE记忆障碍精神异常癫痫 MRI 肿瘤病灶抗神经肿瘤抗原抗体抗细胞表面抗原抗体　出处：《华中科技大学》2013年硕士论文　论文类型：学位论文

【摘要】：目的分析副肿瘤边缘性脑炎（PLE）的特点，提高对该疾病的认识。方法通过对2000年-2011年收住我科的2例及文献检索的11例[1-7]PLE患者的临床资料，结合文献进行回顾性分析。结果该病主要表现为急性或亚急性起病，首发症状为记忆障碍、精神异常，常常有癫痫发作，病程前后发现肿瘤病灶。典型MRI影像学改变表现为单侧或双侧边缘叶T2WI高信号,FLAIR图像病灶更清晰，增强扫描不强化或有轻度小斑片状强化。结论PLE临床表现缺乏特异性，易漏诊、误诊，，为此，需提高对该疾病的认识，早期明确诊断，筛查原发隐匿肿瘤。
[Abstract]:Objective to analyze the characteristics of paraneoplastic marginal encephalitis (PLE) and to improve the understanding of the disease. Methods from 2000 to 2011, 2 cases of our department and 11 cases of literature retrieval were collected. [The clinical data of PLE patients were retrospectively analyzed in combination with literature. Results the main symptoms of the disease were acute or subacute onset, the first symptom was memory disorder, mental disorder, often epileptic seizures. Tumor lesions were found before and after the course of the disease. Typical MRI imaging features were higher intensity flair images on unilateral or bilateral marginal lobes on T2WI. The enhancement scan was not enhanced or slightly patchy enhancement. Conclusion the clinical manifestations of PLE are lack of specificity, easy to be missed and misdiagnosed. Therefore, it is necessary to improve the understanding of the disease, to make early diagnosis and to screen the primary occult tumor.
【学位授予单位】：华中科技大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R512.3

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