中国初治HIV-1感染者司坦夫定治疗6个月后转换为齐多夫定为主的HAART的疗效及安全性研究

发布时间：2018-02-09 09:50

本文关键词： 型艾滋病病毒高效抗反转录病毒治疗齐多夫定司坦夫定　出处：《中国艾滋病性病》2015年07期 　论文类型：期刊论文

【摘要】：目的评价司坦夫定(D4T)治疗6个月后,转换为齐多夫定(AZT)为主的高效抗反转录病毒治疗(HAART)的疗效和安全性。方法 2009年1月到2011年11月,募集201例初治1型艾滋病病毒(HIV-1)感染者,给予D4T治疗6个月后转换为AZT为主的HAART,随访96周,并对免疫学应答和病毒学应答进行评估以及不良反应监测。结果 HAART 96周时,病毒载量(VL)下降(3.20土0.91)lg拷贝/mL;VL40拷贝/mL的比例为94.0%,VL400拷贝/mL的比例为99.0%。CD+4T淋巴细胞从161(83、249)个/μL[四分数位间距(IQR)]明显增长至311(234,446)个/μL(IQR)(P0.001)。HAART过程中7.0%(13/185)的病人出现3级以上中性粒细胞减少症,2.2%(4/185)为3级以上贫血;8.6%(16/185)的病人因严重不良反应改换方案或者终止治疗,其中贫血占2.2%(4/185),脂肪分布异常2.2%(4/185),中性粒细胞减少1.6%(3/185),胃肠反应1.6%(3/185),其他1.1%(2/185)。结论 D4T治疗6个月后转换为AZT为主的一线抗病毒治疗方案安全且有效,尤其适合用于资源紧缺的地区。
[Abstract]:Objective to evaluate the efficacy and safety of highly effective antiretroviral therapy (HAART), which was converted to azidovudine (AZT) after 6 months of treatment. Methods from January 2009 to November 2011, 201 patients with newly treated HIV 1 infected with HIV 1 were recruited. HAART, which was converted to AZT after 6 months of D4T therapy, was followed up for 96 weeks, and the immune and virological responses were evaluated and adverse reactions were monitored. The viral load (VLV) dropped 3.20 卤0.91g / mL / 渭 L / 渭 L / 渭 L / 渭 L / 渭 L / 渭 L of 99.0 / 渭 L / 渭 L / 渭 L / 渭 L of 99.00.CD4T lymphocytes / 渭 L / 渭 L / 渭 L / 渭 L / 渭 L IQRO / 渭 L IQRN P 0.001N / HAART patients with more than 3 grades of neutrophilic granulocytes appeared in the process of ART. Cytopenia 2. 2 / 1855. For grade 3 or more, anemia is 8. 6 percent to 16 / 185.) because of severe adverse reactions, patients change programs or terminate treatment. Anemia accounts for 2.2% of the total, fat distribution is abnormal 2.2%, neutrophilic granulocyte decreases 1.6%, gastrointestinal reaction 1.6% 1855, and other 1.1% 185%. Conclusion D4T is a safe and effective first-line antiviral therapy that converts to AZT after 6 months of treatment, especially in areas where resources are scarce.
【作者单位】：中国医学科学院北京协和医院;
【基金】：十二五国家重点科技专项(2012ZX10001003)~~
【分类号】：R512.91

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