鳖甲煎丸联合恩替卡韦治疗慢性乙型肝炎疗效观察

发布时间：2018-02-21 06:03

  本文关键词： 鳖甲煎丸 恩替卡韦 慢性乙型肝炎　出处：《肝脏》2016年03期 　论文类型：期刊论文

【摘要】：目的观察鳖甲煎丸联合恩替卡韦对慢性乙型肝炎患者肝功能、血清肝纤维化指标、细胞免疫功能的影响。方法 115例慢性乙型肝炎患者随机分为两组,治疗组59例给予鳖甲煎丸3 g/次,3次/d,口服,ETV0.5 mg/次,1次/d,口服,疗程48周;对照组56例给予ETV0.5 mg/次,1次/d,口服,疗程48周。治疗前后检测肝功能、肝纤维化指标及细胞免疫功能。结果治疗组治疗后血清透明质酸(HA)、层黏连蛋白(LN)、Ⅲ型前胶原(PCⅢ)、Ⅳ型胶原(Ⅳ-C)较治疗前明显下降(P均0.001),且下降幅度明显优于对照组(P均0.05);治疗组治疗后丙氨酸氨基转移酶(ALT)、球蛋白明显降低(P均0.05),外周血CD4~+、CD4~+/CD8~+明显升高(P均0.05),CD8~+明显下降(P0.05)。结论鳖甲煎丸联合ETV能够促进肝功能恢复,提高机体细胞免疫功能,改善血清肝纤维化指标,安全性与耐受性良好,疗效上显著优于对照组。
[Abstract]:Objective to observe the effects of Biejia Jian Pill combined with entecavir on liver function, serum hepatic fibrosis index and cellular immune function in patients with chronic hepatitis B. methods 115 patients with chronic hepatitis B were randomly divided into two groups. The treatment group (59 cases) were given Biejia decoction pill (3g / d) for 3 times / d, and the control group (56 cases) were given ETV0.5 mg / d for 48 weeks. The liver function was measured before and after treatment, while the treatment group was treated with oral administration of Biejiajian Pill at a dose of 0.5 mg / d for 48 weeks, while in the control group, 56 cases were given ETV0.5 mg / L once a day for 48 weeks before and after treatment. Results after treatment, serum hyaluronic acid (HA), laminin laminin (LN), procollagen 鈪，

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