云南省2010—2013年HIV阳性结核病患者抗结核疗效影响因素

发布时间：2018-03-03 00:37

本文选题：结核病　切入点：艾滋病　出处：《中国公共卫生》2017年03期 　论文类型：期刊论文

【摘要】：目的分析云南省人类免疫缺陷病毒(HIV)阳性结核病(TB)患者抗结核疗效的影响因素。方法利用TB/HIV双重感染防治监控评价体系,分析云南省2010—2013年登记TB患者HIV抗体检测结果,比较HIV阳性TB患者和HIV阴性TB患者的特征及抗结核治疗效果。数据采用单因素χ~2检验,筛选有影响变量进入多因素logistic回归模型,分析影响HIV阳性TB患者治疗成功的因素。结果共登记报告HIV检测阳性TB患者1 526例,HIV阴性TB患者51 838例。与HIV阴性患者比较,HIV阳性TB患者痰涂片阴性比例较高(67.96%vs56.00%,χ~2=327.54,P0.001),复治比例较高(22.87%vs 3.69%,χ~2=1 342.6,P0.001)、治疗成功率较低(88.07%vs 95.81%,χ~2=210.08,P0.001)、非结核死亡率较高(5.77%vs 0.61%,χ~2=524.73,P0.001);诊断肺结核时CD4200个/μL和治疗分类为复治是影响HIV阳性患者抗结核疗效的危险因素。结论及早发现HIV阳性TB患者,结合其CD4水平及时提供抗结核治疗,加强患者随访管理。
[Abstract]:Objective to analyze the influencing factors of anti-tuberculosis efficacy in HIV-positive TB patients in Yunnan Province. Methods the results of HIV antibody detection in TB patients registered in Yunnan Province from 2010 to 2013 were analyzed by using TB/HIV double infection monitoring and evaluation system. To compare the characteristics of HIV positive TB patients and HIV negative TB patients and the effect of anti-tuberculosis treatment, univariate 蠂 ~ 2 test was used to screen the influential variables into the multivariate logistic regression model. Results A total of 1 526 patients with HIV positive TB were registered and reported 51 838 patients with HIV negative TB. Compared with HIV negative patients, the sputum smear negative rate of HIV positive TB patients was higher than that of HIV negative TB patients, 67.96 vs 56.00, 蠂 2 + 327.54%, P 0.001, respectively. The recurrence rate was higher than 22.87% vs 3.69%, 蠂 ~ 2 / 1 342.6% P 0.001, lower success rate (88.07 vs 95.81), 蠂 ~ (2 +) 210.08% (P 0.001), higher non-tuberculosis mortality (5.77% vs 0.61%, 蠂 ~ (2 524.73) P 0.001), CD4200 / 渭 L in diagnosis of pulmonary tuberculosis and treatment classification as a risk factor for the anti-tuberculosis effect of HIV positive patients. To provide anti-tuberculosis therapy in time combined with its CD4 level, and to strengthen the management of patient follow-up.
【作者单位】：云南省疾病预防控制中心结核病防治所;
【分类号】：R512.91;R52

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