妊娠梅毒RPR滴度对围产结局及新生儿血清学转归的影响

发布时间：2018-03-13 09:24

  本文选题：妊娠合并梅毒　切入点：妊娠结局　出处：《南京医科大学学报(自然科学版)》2015年11期 　论文类型：期刊论文

【摘要】：目的:探讨孕母梅毒快速血浆反应试验(rapid plasma regain,RPR)滴度与新生儿RPR阳性率及围生结局关系。方法:对2009年1月1日—2014年2月1日经RPR和梅毒螺旋体颗粒凝集试验筛查,192例妊娠合并梅毒孕母分娩前及其部分新生儿出生时及6月龄时外周血检测,比较孕母RPR滴度与新生儿RPR阳性率、阴转率及不良围生结局的关系。结果:新生儿RPR滴度与孕母呈正相关,孕母RPR滴度1∶1时,新生儿RPR阳性率68.4%;孕母RPR滴度1∶2时,新生儿RPR阳性率87.0%;当孕母RPR滴度≥1∶8时,新生儿RPR阳性率100.0%;孕母RPR滴度≥1∶8与≤1∶4比较,新生儿RPR阳性率差异有统计学意义(P0.05)。孕母RPR滴度≥1∶8时,婴儿6月龄RPR阴转率下降,与RPR滴度≤1∶4比较,差异有统计学意义(P0.05)。随着孕母RPR滴度的升高,畸形、死胎及新生儿死亡、早产及先天性梅毒的风险升高,婴儿不良结局风险升高。当孕母RPR滴度≥1∶8时,与孕母RPR滴度≤1∶4比较,新生儿畸形、早产、先天性梅毒增多,差异有统计学意义(P0.05)。结论:随着孕母RPR滴度的升高,新生儿RPR阳性率升高,当RPR滴度≥1∶8时,新生儿RPR阳性率为100%,6月龄阴转率下降,胎儿畸形、早产、先天性梅毒发生率显著升高。
[Abstract]:Objective: to investigate the relationship between the titer of rapid plasma response test (RPR) and neonatal RPR positive rate and perinatal outcome. Methods: RPR and Treponema pallidum particle agglutination test were performed from January 1st 2009 to February 2014 to screen the pregnant women with syphilis Treponema pallidum granulocyte agglutination test. Peripheral blood was detected in 192 pregnant women with syphilis before delivery and at birth of some newborns and at the age of 6 months. Results: there was a positive correlation between neonatal RPR titer and maternal adverse perinatal outcome. Results: at 1: 1 RPR titer of pregnant mother, the positive rate of neonatal RPR was 68.4%, and that of maternal RPR titer was 1: 2. The positive rate of neonatal RPR was 87.0.The positive rate of neonatal RPR was 100.0when the RPR titer of pregnant mother was 鈮，

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