IL-10R基因多态性与乙型肝炎病毒感染慢性化的相关性

发布时间：2018-03-20 23:16

本文选题：乙型肝炎病毒　切入点：单核苷酸多态性　出处：《安徽医科大学学报》2015年05期 　论文类型：期刊论文

【摘要】：目的探讨IL-10R基因多态性与乙型肝炎病毒(HBV)感染后慢性化的相关性。方法收集501例慢性HBV感染患者和301例急性自限性HBV感染患者外周血标本,两组患者的年龄、性别和地区来源均相互匹配。Snapshot方法检测IL-10R两个tag SNP(rs2228055、rs2256111)的基因型;χ2检验用于比较两组间基因型及等位基因频率分布。结果 IL-10R基因rs2228055、rs2256111多态等位基因和基因型频率在两组中的分布均符合Hardy-Weinberg平衡。IL-10R基因rs2228055位点G/G基因型频率(7.2%)明显低于急性自限性HBV感染患者(13.0%),差异有统计学意义(P0.05);GG基因型在HBV感染慢性化的风险是AG+AA基因型的0.52倍(OR=0.52,95%CI:0.32~0.84)。结论IL-10R rs2228055位点GG基因型在HBV感染后的慢性化中发挥保护作用。
[Abstract]:Objective to investigate the association between IL-10R gene polymorphism and chronic hepatitis B virus (HBV) infection. Methods the peripheral blood samples of 501 patients with chronic HBV infection and 301 patients with acute self-limited HBV infection were collected. The genotype of IL-10R two tag SNPrs2228055rs2256111) was detected by using the method of gender and region matching. 蠂 2 test was used to compare the distribution of genotype and allele frequency between the two groups. Results IL-10R gene rs2228055 / rs2256111 polymorphism allele and genotype frequency were detected in both groups. The frequency of G / G genotype in rs2228055 locus of Hardy-Weinberg equilibrium. IL-10R gene was significantly lower than that in patients with acute self-limited HBV infection. The risk of chronic HBV infection was 0.52 times higher than that of AG AA genotype. The distribution of GG genotype in patients with acute self-limited HBV infection was significantly lower than that in patients with acute self-limited HBV infection. Conclusion the GG genotype of IL-10R rs2228055 site plays a protective role in chronic HBV infection.
【作者单位】：安徽医科大学第二附属医院肝病科;
【基金】：国家自然科学基金(编号:81273142)
【分类号】：R512.62

【共引文献】