血必净注射液辅助治疗重症腹腔感染对辅助性T淋巴细胞和树突细胞的影响

发布时间：2018-03-27 23:17

  本文选题：血必净注射液　切入点：重症腹腔感染　出处：《中药材》2015年10期

【摘要】：目的:探讨血必净注射液辅助治疗重症腹腔感染对患者T淋巴细胞和树突细胞的影响。方法:78例重症腹腔感染患者随机分为对照组和观察组,两组患者均接受常规治疗,观察组患者在常规治疗的基础上接受血必净注射液治疗。治疗前及治疗2周抽取患者静脉血,采用流式细胞术测定T淋巴细胞和树突细胞水平,记录两组患者入院时及治疗2周时的APACHEⅡ评分和胃肠功能评分,比较两组患者SIRS消退时间、肠功能恢复时间、住院时间、住院病死率及MODS发生率。结果:(1)治疗2周时观察组患者外周血CD3~+、CD4~+和CD4~+/CD8~+水平均较对照组患者显著升高(P0.01),而CD8~+水平较对照组患者显著降低(P0.01);(2)治疗2周时观察组患者外周血CD1α、CD80、CD83和CD86水平均较对照组患者显著升高(P0.01);(3)治疗2周时观察组患者APACHEⅡ评分和胃肠功能评分均较对照组患者降低(P0.01);(4)观察组患者肠功能恢复时间、SIRS消退时间和住院时间均较对照组患者显著缩短(P0.01),MODS发生率和住院病死率较对照组患者显著降低(P0.05)。结论:血必净注射液辅助治疗重症腹腔感染具有较好的临床疗效,并能调节T淋巴细胞和树突细胞进而改善患者免疫功能。
[Abstract]:Objective: to investigate the effect of Xuebijing injection on T lymphocytes and dendritic cells in patients with severe abdominal infection. Methods: 78 patients with severe abdominal infection were randomly divided into two groups: control group and observation group. The patients in the observation group were treated with Xuebijing injection on the basis of routine treatment. Venous blood was drawn from the patients before and after 2 weeks of treatment. The levels of T lymphocytes and dendritic cells were measured by flow cytometry. The APACHE 鈪，

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