人脐带间充质干细胞辅助治疗对乙肝肝硬化患者肝功能、纤维化指标及炎症程度的影响

发布时间：2018-03-30 07:34

  本文选题：乙肝肝硬化　切入点：人脐带间充质干细胞　出处：《海南医学院学报》2016年11期

【摘要】：目的:分析人脐带间充质干细胞辅助治疗对乙肝肝硬化患者肝功能、纤维化指标及炎症程度的影响。方法:选取经本院诊治的乙肝肝硬化患者80例纳入研究,按照接受治疗方式不同,所有纳入对象被分为观察组及对照组各40例。对照组接受常规治疗,观察组接受人脐带间充质干细胞辅助治疗,对比两组肝功能指标、肝纤维化指标、炎症相关指标、病情相关指标水平差异。结果:观察组治疗后血清ALB、GLB、A/G值高于对照组,α2-M、TB、APO-A1、GGT值低于对照组,差异具有统计学意义(P0.05);观察组治疗后血清HA、LN、CIV、PⅢNP、PLD值均低于对照组,差异具有统计学意义(P0.05);观察组治疗后血清TGF-β1、PCT、WBC、SIL-2R水平值均低于对照组,差异具有统计学意义(P0.05);观察组经治疗后血清FT3、ADP值高于对照组,NO、EGF、ADM、IR值低于对照组,差异具有统计学意义(P0.05)。结论:乙肝肝硬化患者接受人脐带间充质干细胞辅助治疗,可以优化肝功能并抑制病情进展,具有积极的临床意义。
[Abstract]:Objective: to analyze the effect of human umbilical cord mesenchymal stem cells (HMSCs) on liver function, fibrosis index and inflammation in patients with hepatitis B. methods: 80 patients with hepatitis B cirrhosis treated in our hospital were included in the study. According to the different methods of treatment, all the subjects were divided into observation group (n = 40) and control group (n = 40). The control group received routine treatment, the observation group received human umbilical cord mesenchymal stem cell adjunct therapy, and the liver function index and hepatic fibrosis index were compared between the two groups. Results: after treatment, the level of serum ALBN GLBN A / G in the observation group was higher than that in the control group, and the GGT value of 伪 2-MN TBX APO-A1G was lower than that in the control group, the difference was statistically significant (P 0.05), and the serum levels of HALNNU CIVP 鈪，

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