扬州市2012—2013年HIV确证实验结果分析

发布时间：2018-03-30 09:52

本文选题：免疫印迹法法　切入点：HIV-抗体　出处：《江苏预防医学》2016年04期

【摘要】：目的了解扬州市HIV初筛阳性病例确证情况及免疫印迹试验(Western Blot,WB)带型分布特点,为艾滋病防治工作提供科学依据。方法应用WB进行HIV抗体确证检测。分析不同性别、年龄组和感染途径人群确证带型差异。结果2012—2013年,扬州市HIV初筛阳性率0.056%,经WB确证,228例为HIV-1抗体阳性病例,确证阳性率87.35%,主要为男性(89.47%)、已婚(75.44%);主要来源于自愿咨询检测(39.91%)和住院及术前检测者(34.21%);主要感染途径为经性接触(97.37%)。HIV-1抗体阳性者、不确定者及阴性者初筛S/CO值差异有统计学意义(P0.01)。gp160阳性率最高(100.00%),p55最低(32.89%)。全带型占24.12%,不同感染途径阳性率差异有统计学意义(P0.05);不同年龄组p51阳性率差异有统计学意义(P0.05)。24例不确定病例中有9例经随访为阳性,其早期带型均为gp160和p24。结论 HIV初筛假阳性率较高,须经复检、WB确证。不确定病例中,应将早期出现gp160和p24带型的病例作为高度疑似HIV感染者进行重点随访。建议加强HIV的监测与健康教育,进一步推进PITC,及早发现感染者,减少疾病的传播风险。
[Abstract]:Objective to understand the Yangzhou city HIV screening positive cases were confirmed and immunoblotting test (Western Blot, WB) distribution belt, and provide scientific basis for AIDS prevention and control. Methods WB HIV antibody. The analysis of different gender, age groups and infected population with type differences. The results confirmed 2012 - 2013, Yangzhou HIV positive rate of 0.056%, confirmed by WB, 228 cases were HIV-1 positive cases, the positive rate was 87.35%, mainly for men (89.47%), married (75.44%); mainly from voluntary counseling and testing (39.91%) detection and hospital stay and preoperative patients (34.21%); the main route of infection is through sexual contact (97.37%).HIV-1 antibody positive, negative and uncertain screening S/CO value difference was statistically significant (P0.01) positive rate of.Gp160 is the highest (100%), p55 (32.89%). The lowest zone type accounted for 24.12%, there was statistically significant difference between the positive rate of different routes of infection Yi (P0.05); there was significant difference of the positive rate in different age groups of p51 (P0.05).24 cases confirmed cases in 9 cases were positive, the early bands were gp160 and p24. conclusion HIV screening high false positive rate, subject to review, WB confirmed. Uncertain cases, should be the early stage of gp160 and p24 with cases as highly suspected HIV infection were followed up. The key recommendations to strengthen monitoring and health education to further promote the HIV, PITC, early detection of infection, reduce the spread of disease risk.

【作者单位】：江苏省扬州市疾病预防控制中心;
【分类号】：R512.91

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