HBV共感染对不同类型肝包虫患者肝脏功能的影响

发布时间：2018-04-10 14:04

本文选题：囊型包虫病(CE) + 泡型包虫病(AE)　；参考：《西安交通大学学报(医学版)》2017年05期

【摘要】：目的分析乙型肝炎病毒(HBV)共感染对不同类型肝包虫病患者肝脏功能的影响。方法收集我国西部地区医院2014年至2015年期间确诊为肝包虫病的患者409例,抽取静脉血检测所有患者的肝功能指标;采用ELISA方法进行HBV表面抗原血清阳性测试;卡方检验明确HBV共感染在不同类型肝包虫病中的流行情况。以是否感染HBV为标准分组,以不同类型肝包虫病分层,对比HBV病毒共感染对不同类型肝包虫病患者肝脏功能的影响。结果肝包虫病患者共感染HBV后出现转氨酶升高、白蛋白降低等更为严重的肝脏功能损伤。与囊型肝包虫病患者相比,以多房棘球绦虫为病原体的泡型肝包虫病患者发生HBV病毒共感染的机会更高(38.4%vs.86.4%),差异具有统计学意义(P0.05)。分层分析结果显示,以细粒棘球绦虫为病原体的囊型肝包虫病患者共感染HBV比无HBV共感染者肝脏功能损伤无统计学意义;但是以多房棘球绦虫为病原体的泡型肝包虫病共感染HBV患者较之无HBV共感染者表现出更为严重的肝脏损伤,肝功能指标显著下降(P均0.05)。结论泡型肝包虫病患者更容易出现HBV病毒共感染,并且会导致更严重的肝脏损伤,在临床治疗中需要特别重视。
[Abstract]:Objective to analyze the effect of hepatitis B virus (HBV) co-infection on liver function in patients with different types of hepatic hydatid disease.Methods 409 patients diagnosed with hepatic hydatid disease from 2014 to 2015 were collected from western hospitals in China. The liver function indexes of all patients were detected by venous blood samples, and HBV surface antigen seropositive test was performed by ELISA method.Chi square test confirmed the prevalence of HBV co-infection in different types of hepatic hydatid disease.The effect of HBV co-infection on liver function of patients with different types of hepatic hydatid disease was compared by using different types of liver hydatid disease as stratification according to whether they were infected with HBV or not.Results after co-infection of HBV in patients with hepatic hydatid disease, transaminase increased and albumin decreased.Compared with the patients with cystic hepatic hydatid disease, patients with Echinococcus multilocularis were more likely to develop HBV co-infection than those with hydatid disease with Echinococcus multilocularis as pathogen. The difference was statistically significant (P 0.05).The results of stratified analysis showed that there was no significant difference in liver function damage in patients with hydatid disease with Echinococcus granulosus (Echinococcus granulosus) co-infected with HBV compared with those without HBV.However, Echinococcus multilocularis co-infected HBV patients showed more severe liver damage than those without HBV co-infection, and the liver function index decreased significantly (P 0.05).Conclusion patients with alveolar hepatic hydatid disease are more likely to co-infection with HBV virus and lead to more serious liver injury, which should be paid more attention to in clinical treatment.
【作者单位】：西安交通大学第一附属医院肝胆外科;青海大学附属医院肝胆胰外科;中国人民解放军第四医院肝胆外科;
【分类号】：R512.62;R532.32

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