舍曲林联合普瑞巴林治疗老年带状疱疹后神经痛镇痛疗效的研究

发布时间：2018-04-24 02:04

本文选题：带状疱疹后神经痛 + 舍曲林　；参考：《中国临床药理学杂志》2015年02期

【摘要】：目的评价舍曲林联合普瑞巴林治疗老年带状疱疹后神经痛的临床疗效。方法 60例老年带状疱疹后神经痛患者随机分为对照组(n=32)和试验组(n=28)。对照组用普瑞巴林150 mg·d-1,试验组在对照组基础上加用舍曲林50mg·d-1,2组均常规营养神经药物治疗及物理治疗。治疗前、治疗后4周用视觉模拟评分(VAS)评估患者的疼痛强度变化,中文版简明健康测量量表(SF-36)评定生活质量的变化。结果 2组治疗后疼痛强度均较治疗前显著降低(P0.05),试验组疼痛缓解显著高于对照组(P0.05)。试验组在6个领域的生活质量较对照组明显改善(P0.05)。2组不良反应发生率差异无统计学意义。结论舍曲林联合普瑞巴林能提高老年带状疱疹后神经痛的疗效。
[Abstract]:Objective to evaluate the clinical efficacy of sertraline combined with PreBahrain in the treatment of postherpetic neuralgia in the elderly. Methods 60 elderly patients with postherpetic neuralgia were randomly divided into control group (n = 32) and experimental group (n = 28). The control group was treated with Premarin 150mg / d, the experimental group was treated with sertraline 50mg d-1G on the basis of the control group, and the control group was treated with routine nutritional neuromedication and physical therapy. Before and 4 weeks after treatment, the changes of pain intensity were evaluated by visual analogue scale (VASs), and the quality of life (QOL) was assessed by SF-36 (Chinese version). Results the pain intensity after treatment in both groups was significantly lower than that before treatment, and the pain relief in the trial group was significantly higher than that in the control group. There was no significant difference in the incidence of adverse reactions in the six areas of the trial group compared with the control group. Conclusion Sertraline combined with PreBahrain can improve the efficacy of post-herpes zoster neuralgia in the elderly.
【作者单位】：宁波市第一医院老年科;
【分类号】：R752.12

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