白藜芦醇联合齐多夫定对免疫抑制小鼠的影响

发布时间：2018-04-27 11:37

本文选题：白藜芦醇 + 齐多夫定　；参考：《中华中医药杂志》2015年02期

【摘要】：目的:探讨白藜芦醇联合齐多夫定对环孢菌素A所致的免疫抑制小鼠免疫重建功能的影响。方法:通过腹腔注射环孢菌素A建立小鼠免疫抑制模型。实验设白藜芦醇联合齐多夫定组(联合组)、白藜芦醇组、齐多夫定组、贞芪颗粒组、模型组、溶液组和空白组,灌胃1周后,观察小鼠脾脏、胸腺的脏器指数和病理变化;CD4+T、CD8+T细胞亚群比率及其比值。结果:1脏器指数:与空白组和溶液组比较,模型组胸腺指数下降(P0.05);与模型组比较,联合组和白藜芦醇组胸腺指数上升明显(P0.01);2病理变化:与空白组和溶液组相比,模型组脾白髓质部分扩大,有较多的多核巨噬细胞;胸腺萎缩,皮质增厚,发生质变,联合组和白藜芦醇组改善明显;3T细胞亚群:与空白组和溶液组比较,模型组CD4+、CD8+T细胞亚群比例及比值下降(P0.05)。与模型组比较,联合组CD4+、CD8+T细胞亚群比例上调(P0.05,P0.01)。结论:针对环孢菌素A所致的免疫抑制小鼠模型,联合组具有一定的免疫重建作用。
[Abstract]:Objective: To investigate the effect of resveratrol combined with zidovudine on the immune reconstructive function of immunosuppressed mice induced by cyclosporin A. Methods: the Immunosuppressive Model of mice was established by intraperitoneal injection of cyclosporin A. The experiment set up resveratrol combined with zidovudine group (joint group), resveratrol group, Zidorf set group, Zhen Qi granule group, model group, dissolution test. In the liquid group and the blank group, the spleen and thymus index and pathological changes of the thymus were observed after 1 weeks of gavage. The ratio and ratio of CD4+T, CD8+T cell subgroup and its ratio. Results: the index of the 1 organ index: compared with the blank group and the solution group, the thymus index of the model group decreased (P0.05), and the thymus index of the combined group and the resveratrol group increased significantly (P0.01), 2 Pathological changes: compared with the blank group and the solution group, the splenic white medulla part of the model group expanded and had more multinucleated macrophages; the thymus atrophy, the cortex thickening, the qualitative change, the combination group and the resveratrol group improved obviously; the 3T cell subgroup: compared with the blank group and the solution group, the ratio and ratio of the CD4+, CD8+T cell subgroup and the ratio decreased (P0.05) in the model group. Compared with the model group, the proportion of CD4+ and CD8+T cells in the combined group was up to up (P0.05, P0.01). Conclusion: the combined group has a certain immune reconstructive effect against the immunosuppressive mice induced by cyclosporin A.

【作者单位】：湖南中医药大学;
【基金】：湖南省科技厅课题(No.2013SK3097) 湖南省高校科技创新团队资助项目(No.15) 湖南中医药大学重点学科《基础医学》《病原生物学》资助项目(No.1)~~
【分类号】：R512.91

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