2009-2016年临海市手足口病病原学监测结果分析

发布时间：2018-04-30 05:41

本文选题：手足口病 + 病原学　；参考：《中国病原生物学杂志》2017年06期

【摘要】：目的了解临海市近年手足口病疫情和病毒株流行情况,为该病的预防和控制提供科学指导。方法应用荧光定量RT-PCR对临海市2009-2016年采集的手足口病患者和健康密切接触者咽拭子标本进行病原学检测,采用Excel2003和SPSS19.0软件进行数据录入和分析。结果共采集咽拭子标本537份,荧光定量RT-PCR检测手足口病病毒299份阳性,总阳性率为55.68%,其中肠道病毒EV71型阳性79份,阳性率14.71%,占所有阳性标本的26.42%;科萨奇Cox A16型56份阳性,阳性率10.43%,占所有阳性标本的18.73%;其他肠道病毒阳性164份,阳性率30.54%,占阳性标本的54.85%。结论临海市引起手足口病的病毒以EV71和CoxAl6型最为常见,重症手足口病病原以EV71为主。因此,掌握手足口病的流行规律和病原学特征,对进行更有效的防控有重要意义。
[Abstract]:Objective to investigate the epidemic situation of hand, foot and mouth disease (HFMD) and virus strains in Linhai City in recent years and to provide scientific guidance for the prevention and control of HFMD. Methods fluorescence quantitative RT-PCR was used to detect the etiology of pharynx swab samples of hand-foot-mouth disease patients and healthy close contacts collected from 2009 to 2016 in Linhai City. The data were recorded and analyzed by Excel2003 and SPSS19.0 software. Results A total of 537 pharyngeal swabs were collected and 299 cases of HFMD virus were detected by fluorescence quantitative RT-PCR. The total positive rate was 55.68, of which 79 were positive for enterovirus EV71 type, 14.71 were positive for intestinal virus type EV71, accounting for 26.42% of all positive specimens, 56 samples were positive for Cox A16. The positive rate was 10.43%, accounting for 18.73% of all positive specimens, while 164 cases of other enterovirus were positive, and the positive rate was 30.54%, accounting for 54.85% of the positive specimens. Conclusion EV71 and CoxAl6 are the most common viruses causing HFMD in Linhai, and EV71 is the main pathogen of HFMD. Therefore, mastering the epidemic law and etiological characteristics of hand, foot and mouth disease is of great significance for more effective prevention and control.
【作者单位】：临海市疾病预防控制中心;
【分类号】：R181.8;R512.5

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