扶正化瘀胶囊联合阿德福韦酯治疗慢性乙型肝炎的临床疗效和机制研究

发布时间：2018-05-01 05:24

本文选题：乙型肝炎 + 扶正化瘀胶囊　；参考：《中国全科医学》2015年10期

【摘要】：目的了解扶正化瘀胶囊联合阿德福韦酯治疗慢性乙型肝炎(乙肝)的临床疗效,并探讨其相应机制。方法选取2011年4月—2013年2月在湖州市中心医院住院治疗且符合本研究纳入及排除标准的乙肝患者134例,按随机分组原则,将其分为对照组和试验组各67例。对照组采用阿德福韦酯治疗,试验组采用扶正化瘀胶囊联合阿德福韦酯治疗,均连续治疗1年,比较2组患者的各项临床指标。结果治疗前,2组患者CD40、CD11C、CD86、HBV-DNA、HBV-DNA阴性(DNA-)、γ干扰素(IFN-γ)及树突状细胞(DCs)刺激活性比较,差异无统计学意义(P0.05)。治疗后,2组患者CD40、CD11C、CD86、HBV-DNA、DNA-、IFN-γ及DCs刺激活性与治疗前比较,差异有统计学意义(P0.05)。治疗后,2组患者的CD40、CD11C、CD86、HBV-DNA、DNA-、IFN-γ比较,差异有统计学意义(P0.05);DCs刺激活性比较,差异无统计学意义(P0.05)。结论扶正化瘀胶囊联合阿德福韦酯可以较好地改善乙肝患者的DCs功能,临床治疗效果较好。
[Abstract]:Objective to investigate the clinical effect of Fuzheng Huayu capsule combined with adefovir ester in the treatment of chronic hepatitis B and to explore its mechanism. Methods 134 cases of hepatitis B patients who were hospitalized in Huzhou Central Hospital from April 2011 to February 2013 and met the criteria of inclusion and exclusion in this study were divided into control group (67 cases) and experimental group (67 cases) according to the principle of random grouping. The control group was treated with adefovir ester, the experimental group was treated with Fuzheng Huayu capsule combined with adefovir ester for one year, and the clinical indexes of the two groups were compared. Results before treatment, there was no significant difference in the stimulating activity of CD40, CD11Cnct86nHBV-DNA, IFN- 纬 and dendritic cell (DCS) between the two groups (P 0.05P = 0.05P < 0.05), but no significant difference was found between the two groups in the activity of HBV-DNA negative and IFN- 纬 (IFN- 纬) and dendritic cell (DCS) stimulation activity. After treatment, there were significant differences in the activity of CD40, CD11, CD86, HBV-DNA, DNA-n- 纬 and DCs stimulation between the two groups compared with those before treatment (P 0.05). After treatment, there was a significant difference in the stimulating activity of CD40, CD11, CD86, HBV-DNA, DNA-n- 纬 between the two groups, but there was no significant difference in the stimulating activity of DCs between the two groups (P 0.05). Conclusion Fuzheng Huayu capsule combined with adefovir ester can improve the DCs function of hepatitis B patients, and the clinical effect is better.
【作者单位】：浙江省湖州市中心医院消化内科;浙江省湖州市中心医院感染内科;
【基金】：浙江省医药卫生科技计划(2009B152)
【分类号】：R512.62

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