长春市结核病定点医院肺结核患者耐药状况

发布时间：2018-05-13 05:29

  本文选题：结核 + 肺　； 参考：《中国公共卫生管理》2016年06期

【摘要】：目的了解长春市住院肺结核患者结核分枝杆菌耐药状况,分析住院患者耐药菌谱为进一步指导临床用药方案提供依据。方法选择2012年5月至2013年12月长春市各县区结防机构推送及长春市结核病定点医院确诊的长春地区痰涂片阳性肺结核患者801例,复治487例,初治314例,采用传统罗氏国体培养法和比例法对痰标本进行结核分枝杆菌培养及药物敏感试验。结果 801份痰标本培养阳性菌株747株,结核分枝杆菌中任意耐药菌株426例(57.03%),其中初治患者和复治患者任意耐药率分别为40.07%(115/287)、75.43%(347/460),复治患者任意耐药率明显高于初治患者(χ~2=93.67,P0.05)。初治患者与复治患者对异烟肼、利福平、氧氟沙星单耐药率相近,差异无统计学意义。耐2种(χ~2=22.89)、耐3种(χ~2=75.98)及耐多药(χ~2=88.37)、广泛耐药(χ~2=9.52)差异有统计学意义(P0.05),25~54岁耐多药及广泛耐药率高于其他年龄段(P0.05)。结论涂阳肺结核患者耐药率严重,复治患者为主要耐药人群,重症初治涂阳病人耐药情况不容忽视。
[Abstract]:Objective to investigate the drug resistance of Mycobacterium tuberculosis in pulmonary tuberculosis patients in Changchun City, and to analyze the spectrum of drug resistance bacteria in patients with pulmonary tuberculosis. Methods from May 2012 to December 2013, 801 pulmonary tuberculosis patients with sputum smear positive in Changchun were selected, 487 cases were re-treated and 314 cases were initially treated. Mycobacterium tuberculosis culture and drug sensitivity test were carried out in sputum specimens by traditional Roche's body culture method and proportional method. Results among 801 sputum specimens, 747 strains were positive and 426 strains were arbitrarily resistant in Mycobacterium tuberculosis. Among them, the rate of arbitrary drug resistance was 40.07% in the first treatment group and 75.43% in the retard group (P 0.05). The rate of arbitrary drug resistance in the re-treated patients was significantly higher than that in the initial treatment patients (蠂 ~ 2P _ (93.67) P _ (0.05). The rates of isoniazid, rifampicin and ofloxacin resistance to isoniazid, rifampicin and ofloxacin were similar between primary and recurrent patients, but the difference was not statistically significant. The rates of multidrug resistance (MDR) and multidrug resistance (MDR) were significantly higher than those in other age groups (蠂 ~ (2 +) = 22.89, 蠂 ~ (2 +) = 75.98) and multidrug resistance (蠂 ~ (2 +) = 88. 37, 蠂 ~ (2 +) = 29. 52). The rates of multidrug resistance (MDR) and wide drug resistance (MDR) in 2554 years old were significantly higher than those in other age groups (P 0. 05). Conclusion the drug resistance rate of smear positive pulmonary tuberculosis patients is serious.
【作者单位】： 长春市传染病医院;
【分类号】：R521
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本文编号：1881879