106例复治痰涂片阳性肺结核患者的痰培养及耐药性分析

发布时间：2018-05-13 16:38

本文选题：涂阳肺结核 + 复治　；参考：《中国卫生检验杂志》2016年22期

【摘要】：目的收集天津市结核病控制中心首次治疗失败的结核病患者的耐药情况,为复发患者制定合理化方案提供参考。方法纳入者从2010年1月-2014年12月选取有痰培养阳性结果以及药物敏感性试验结果的患者。所有纳入患者的痰培养结果分别进行6种抗结核药物敏感性检测。结果 106例复治痰涂片阳性肺结核患者中出现18例痰培养阴性,其余88例痰培养阳性中,出现耐药情况55例,耐药者占51.89%,单耐药率为17.05%,多耐药率为5.68%,耐多药率为14.77%,耐多药以耐3种~4种药物的患者较多,共11例,占全部耐多药患者的84.62%。结论复治痰涂片阳性的肺结核患者耐药率及耐多药率较高,且耐多药中耐3种以上药物居多,应重视广泛耐药情况的发生。当前的标准化复治肺结核方案患者应及时关注痰培养及药敏试验结果,以指导下一步治疗。
[Abstract]:Objective to collect the drug resistance of tuberculosis patients who failed in the first treatment in Tianjin TB Control Center, and to provide reference for the rational plan of relapse patients. Methods patients with positive sputum culture and drug sensitivity test were selected from January 2010 to December 2014. The results of sputum culture in all patients were tested for the sensitivity of 6 anti-tuberculosis drugs. Results among 106 patients with re-treated sputum smear positive pulmonary tuberculosis, there were 18 cases with negative sputum culture, and 55 cases with drug resistance among the remaining 88 cases of sputum culture positive. The drug resistance rate was 51.89, the rate of single drug resistance was 17.05, the rate of multi-drug resistance was 5.68, the rate of multi-drug resistance was 14.777.The number of patients with multi-drug resistance to three or four drugs was 11, accounting for 84.62% of all patients with multi-drug resistance. Conclusion the rate of drug resistance and multidrug resistance of tuberculosis patients with positive sputum smear is higher, and more than 3 kinds of drugs are more resistant in multidrug resistance, so we should pay attention to the occurrence of extensive drug resistance. The current standardized relapse regimen should pay attention to the results of sputum culture and drug sensitivity test in order to guide the next treatment.
【作者单位】：天津市结核病控制中心;天津医科大学公共卫生学院;
【分类号】：R52

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