应用实时剪切波弹性成像评价替比夫定对慢性乙型病毒肝炎肝纤维化的治疗效果初步研究

发布时间：2018-05-13 17:25

  本文选题：肝炎 + 乙型　； 参考：《中国临床医学影像杂志》2015年06期

【摘要】：目的:应用实时剪切波弹性成像技术测定慢性乙型病毒肝炎患者肝脏杨氏模量值,评价替比夫定对慢性乙型病毒肝炎肝纤维化治疗效果。方法:选择慢性乙型病毒肝炎肝纤维化患者80名(均在治疗前进行肝活检),A组(S0,S1)22例,B组(S2,S3)40例,C组(S4)18例,所有患者进行替比夫定药物治疗,分别在治疗前和治疗后24周进行实时剪切波弹性成像测量肝脏杨氏模量值和血清学检查,包括透明质酸(Hyaluronic acid,HA)、层黏蛋白(LN)、三型前胶原N端肽(PⅢPN-P)、Ⅳ型胶原(CL-Ⅳ),比较各参数治疗前后变化。结果 :所有A、B、C 3组血清学指标HA、LN、PⅢPN-P、CL-Ⅳ治疗24周后均较治疗前降低,差异均有统计学意义(P0.05),而所有A、B、C 3组实时剪切波弹性测量肝脏杨氏模量值治疗后均比治疗前降低,差异均有统计学意义(P0.05)。治疗前与治疗后实时剪切波弹性测量肝脏杨氏模量值均为A组B组C组。结论:实时剪切波弹性成像测量肝脏弹性模量值可以用来对替比夫定治疗慢性乙型肝炎疗效进行评估。
[Abstract]:Aim: to evaluate the therapeutic effect of tibivudine on liver fibrosis of chronic hepatitis B virus by measuring the Young's modulus of liver with real time shear wave elastography. Methods: 80 patients with chronic hepatitis B hepatitis liver fibrosis were selected. All of them were treated with tibivudine in group A (22 cases of S0 S1) and group B (40 cases of S2OS3). All the patients were treated with tibivudine, and all of them were treated with tibivudine. Real time shear wave elastography was performed before and 24 weeks after treatment to measure the Young's modulus of liver and serological examination. It included hyaluronic acididine, laminin (LNN), type 3 procollagen N-terminal peptide (P 鈪，

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